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Novel mechanisms by which vascular smooth muscle cells sense, transduce and respond to extracellular matrix stiffness
Time of Update: 2022-01-23
Here, we report that a collagen receptor in vascular smooth muscle cells, discoid domain receptor 1 (DDR1), acts as a mechanoreceptor to sense increased extracellular matrix stiffness in a ligand-independent manner and mediate Intracellular mechanical signal transduction, inhibits the contractile function of smooth muscle cells and promotes the synthesis of pro-inflammatory factors, causing changes in the microenvironment of the vessel wall and aggravating vascular sclerosis .
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Zhou Jing's team reveals a new mechanism by which vascular smooth muscle cells sense, transduce and respond to extracellular matrix stiffness
Time of Update: 2022-01-23
Here, we report that a collagen receptor in vascular smooth muscle cells, discoid domain receptor 1 (DDR1), acts as a mechanoreceptor to sense increased extracellular matrix stiffness in a ligand-independent manner and mediate Intracellular mechanical signal transduction, inhibits the contractile function of smooth muscle cells and promotes the synthesis of pro-inflammatory factors, causing changes in the microenvironment of the vessel wall and aggravating vascular sclerosis .
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Cell: Small glial cells give way to space for new synaptic formations by devouring extracellular matrixes.
Time of Update: 2020-07-17
!--:page title"--July 12, 2020 // --- In order to create new memories, our brain cells must first find each other small protrusions protruding from the endof of the neurons' long branches of tentacle
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CELL: Small glial cells reshape extracellular matrix and promote synaptic plasticity
Time of Update: 2020-07-14
Synaptic remodeling is essential for coding learning memories into neural loops Recently, researchers discovered a molecular interaction between neurons and small glial cells that drives empirically
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Cell: extracellular matrix affects cancer metastasis by regulating glucose metabolism
Time of Update: 2018-09-12
September 12, 2018 / BIOON / - UCLA researchers have found that extracellular matrix can control the movement of cells in vivo by regulating the sugar consumption of cells Extracellular matrix refers