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Cell Death Dis: KLF4-CD9/CD81-JNK Signaling Pathway Disorder Promotes The Development of Liver Cancer
Time of Update: 2020-05-29
The exosome is the main component of the extracellular cystic bubble (EVs) and is a nanoscale membrane structure between 30 and 150 nm in diameter, which can be secreted by most cell types Many cur
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Professor Yan Ru Tie: HRD test expands the benefit of recurrent ovarian cancer after-line treatment, domestic products are used for the first time in PARPi clinical trial group HRD testing
Time of Update: 2020-05-29
As tumor therapy enters the era of precision, what is the research progress of post-line therapy as the first real target drug PARP inhibitor for ovarian cancer?
What are the biomarkers of the population benefiting from the post-line treatment of PARP inhibitors?
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Blood: CDK6 is a new potential therapeutic target for acute myeloid leukemia with NUP98 fusion protein
Time of Update: 2020-05-29
Fusion proteins associated with nucleoporous protein 98 (NUP98) are repeated in acute myeloid leukemia (AML) and are associated with poor prognosis So far, insufficient understanding of NUP98-fusio
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Blood: E3 connecting enzyme UBR5 mutation regulates lymphoma B cell maturation
Time of Update: 2020-05-29
In order to promote B-cell development, activation and survival, coordination of a variety of molecular mechanisms, including transcription, selective splicing, and type switchre, is required The d
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How can drug-resistant advanced cancers are treated? NT219 of target-to-drug-resistant pathways IRS1/2 and STAT3 is about to conduct Phase I/II clinical trials
Time of Update: 2020-05-29
Kitov, a clinical-stage biotechnology company dedicated to overcoming cancer immunity and drug resistance, recently announced that the FDA has accepted its application for a research drug (IND) to
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JAMA Oncology: O'Nitrogen reduces nausea and vomiting in patients with advanced cancer
Time of Update: 2020-05-29
Otopine is a mental illness drug, and recent research has found that onotapine can also reduce nausea and vomiting in patients with advanced cancer The results were published may 7 in JAMAA Oncolog
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Hepatology: Study finds new mechanism may improve survival rates in patients with hepatocellular carcinoma
Time of Update: 2020-05-29
The use of programmed death receptor-1 (PD-1) to block the activation of anti-tumor immune responses has only shown benefits in a total number of patients with hepatocellular carcinoma (HCC) The co
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A case of cervical large cell neuroendocrine cancer
Time of Update: 2020-05-29
The patient woman, 29 years old, 5 months ago to perform "caesarean section", the birth of a live baby, the duration of the bad dew 52 days; Patients visited the local hospital 7 days ago, TCT prom
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ASCO 2020: PD-1 mono-anti-Opdivo, CTLA-4 mono-Yervoy combination chemotherapy first-line treatment of non-small cell lung cancer, reducing risk of death by 31%
Time of Update: 2020-05-29
Bristol Myers Squibb announced the detailed results of its CheckMate-9LA trial, which showed that the use of PD-1 mono-anti-Opdivo (nivolumab) and CTLA-1 mono-resistant Yervoy (ipilimumab) chemothe
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CELL: Cancer gene ALK helps skinny people not fat
Time of Update: 2020-05-29
Although obesity is the same in most parts of the world, there are considerable individual-to-individual differences in susceptibility to weight gain Although many studies have focused on determi
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Cell Death Dis: INPP4B deficiency affects DNA double-stranded fracture repair by undermining the stability of Rad50
Time of Update: 2020-05-29
Genomic instability is a basic feature of malignant tumors, and many gene mutations and large genome changes, including deletion, translocation, loss of heterogeneity and amplification, are acciden
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Cancer Res: New Ideas for Immunological Treatment for Gastric Cancer
Time of Update: 2020-05-29
On March 10, 2020, Gao Weiqiang of Shanghai Jiaotong University's School of Biomedical Engineering and Ma Bin's team published their research on "Blockade of beta-catenin-induced CCL28 of the Gastr
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Blood: Immunogenomic identification and characteristics of mony myeloma granulocytes inhibition cells
Time of Update: 2020-05-29
Granucytomyde-inhibiting cells (G-MDSCs) promote tumor growth and immunosuppression of multiple myeloma (MM) However, its pintype cannot be accurately detected and used for clinical transformation
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ASCO 2020: MEK162 (Bemetinib) Joint Imatinib Treatment of Advanced Gastrointestinal Interside Tumor phase II Clinical Study
Time of Update: 2020-05-29
BACKGROUND: ETV1 and KIT are the main transcription factors and signal survival factors of the family of gastrointestinal mesothelioma In the preclinical model, BINI inhibited ETV1 and Imatinib inh
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23rd ASGCT: Cell Therapy NTLA-5001 for the treatment of acute myeloid leukemia!
Time of Update: 2020-05-29
Intelli Therapeuticas, a leading genome editing company dedicated to developing therapeutic drugs using CRISPR/Cas9 technology, will present a report at the 23rd annual meeting of the American Soci
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After static injection of yew alcohol, blood pressure dropped to 70/40mmHg, the culprit is...
Time of Update: 2020-05-29
Case review patient male, 59 years old, right lung adenocarcinoma after surgery to receive yew alcohol and cisplatin chemotherapy (TP program) Before chemotherapy 12, 6h injections of dexamethaso
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Cancer Cell Int: Immune-related prognosis biomarkers associated with osteosarcoma microenvironment
Time of Update: 2020-05-29
Osteosarcoma is a highly invasive bone tumor found in children and adolescents The treatment and outcome of osteosarcoma has remained unchanged over the past 30 years The relationship between osteo
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Cell Death Dis: miR-4476/APC/beta-catenin/c-Jun positive feedback ring promotes the development of glioma
Time of Update: 2020-05-29
Glioma is one of the most common primary tumors of the central nervous system (CNS), accounting for 81% of all malignant brain tumors, associated with higher morbidity and mortality According to th
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Cell Death Dis: The Mechanism by cold plasma to induce tumor cell death
Time of Update: 2020-05-29
New physical techniques other than ionizing radiation that can effectively kill cancer cells have been a hot topic of research Cold plasma (CAP) is an ionizing gas close to room temperature, consis
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Cell Death Dis: YY1/miR-548t-5p/CXCL11 pathway regulates proliferation and metastasis of pancreatic cancer cells
Time of Update: 2020-05-29
Pancreatic catheter adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States, with a five-year survival rate of only about 9% Surgery is the only cure for pancreatic c
