CELL: Cancer gene ALK helps skinny people not fat
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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Although obesity is the same in most parts of the world, there are considerable individual-to-individual differences in susceptibility to weight gainAlthough many studies have focused on determining the genetic susceptibility of obesity, researchers recently conducted GWAS studies of metabolically healthy thin people (the lowest six percentiles of the whole population BMI) in a phenotypic Estonian queueresearchers have found a candidate for lean human gene --- non-cell hyperplasia lymphoma kinase (ALK)In fruit flies, RNAi-mediated ALK knocking leads to a decrease in triglyceride levelsIn mice, ALK gene removal led to the animal's thin ness and significant resistance to obesity induced by diet and leptin mutationsthe mechanism, the researchers found that the expression of ALK in hypothalamus neurons controls the energy expenditure of fat-soluble adipose tissue through sympathetic nervesso the genetic and mechanism experiment found that ALK is a slimming gene that is involved in resisting weight gain
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