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Gastroenterology: A global study of trends in pancreatic cancer morbidity and mortality.
Time of Update: 2020-10-28
analysis of data from 184 countries, the study found an increase in the incidence and mortality of pancreatic cancer worldwide, especially among women and people over the age of 50.
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Nat Commun:IL6 Trans-Signal Transductive Path: The Potential Mechanism for Diffuse Cancer Cell Metastasis.
Time of Update: 2020-10-28
IL6 signaling path path in BM-DCCs in breast cancer patients was activated, the study revealed that the initial formation of tumor metastasis is usually not cancer cell autonomy, but depends on micro-environmental-related signals.
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Brit J Cancer: Effects of age on outcomes in patients with soraphini to treat hepatocellular carcinoma.
Time of Update: 2020-10-28
recently, a study published in British Journal of Cancer, an authoritative journal in the field of oncology, was designed to assess whether age affects total survival (OS) and whether lowering the starting dose affects OS or toxicity in older adults.
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NEJM: Millions of people data studies have shown that four-price HPV vaccination significantly reduces the risk of immersive cervical cancer.
Time of Update: 2020-10-28
Overall, our study shows that tyrophic HPV vaccination significantly reduces the risk of cervical cancer, especially before age 17," said Jiayao Lei, author of the study.
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"Virus-simulated drugs" help the immune system target cunning cancer cells.
Time of Update: 2020-10-28
most immunotherapy relies on T-cells' ability to recognize and kill tumor cells," said Dr. Anusha Kalbasi, an assistant professor of radiation oncology at the David Geffen School of Medicine at the University of California, Los Angeles.
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J Clin Oncol: Future Available. Karelli pearl single anti-combined apatini to treat advanced cervical cancer!
Time of Update: 2020-10-28
the trial is a multi-center, open-label one-arm Phase II trial that recruits patients with advanced cervical cancer who have previously progressed after at least first-line system treatment.
, Karelli's monoantigen apatinist showed encouraging anti-tumor activity and controlled toxicity in patients with advanced cervical cancer.
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JAMA Surg: Effects of breast reconstruction vs total mastectomy on long-term prognostication in breast cancer patients after breast preservation surgery after new assisted chemotherapy.
Time of Update: 2020-10-28
Breast cancer patients who have the option of a mastectomy (NSM) or skin-retaining mastectomy (SSM) immediately after a new assisted chemotherapy (NACT) have a breast reconstruction (IBR), and researchers recently compared the effects of the breast cancer procedure on patients' long-term oncology results compared to traditional total mastectomy (CM).
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Br J Cancer: A summary analysis of clinical studies of FOLFOXIRI and Beval single anti-treatment metastatic colorectal cancer.
Time of Update: 2020-10-28
first-line reaction and longer OIFI were associated with improved response, second PFS and reintroduity of FOLFOXIRI±bev treatment strategies, but did not affect the second OS phase.
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Nat Commun: Phosphate oxide promotes the dry and immuno-induced properties of pancreatic cancer stem cells.
Time of Update: 2020-10-28
Over the past decade, great progress has been made in the diagnosis and treatment of different cancers; however, this is not the case for pancreatic catheter adenocarcinoma (PDAC), which is now the fourth most common cause of cancer-related deaths and is expected to become the second deadliest tumor by 2030.
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PD-1 monoanti-Opdivo combined with TKI inhibitor Cabometyx to treat kidney cancer, which received FDA priority review.
Time of Update: 2020-10-28
according to CheckMate 9ER data reported a month ago by the European Society of Medical Oncology (ESMO), the combination of Opdivo and Cabometyx reduced the risk of death by 40 per cent compared to Pfizer's Sunitinib, sutent, after a median 18-month follow-up.
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Nat Commun:c-Myc activates the pan-cancer expression lncRNA MILIP inactivated p53 and induces cancer.
Time of Update: 2020-10-28
Previous studies have shown that the protocancer protein c-Myc and tumor suppressor p53 are inextricable relationships in regulating normal cell survival and proliferation, and that their function also maintains a steady state of tissue: c-Myc can induce The expression of ARF tumor inhibitors, which then bind and inhibit the expression of MDM2, eventually causes the activation of p53, which inhibits c-Myc through a variety of mechanisms, including transcriptional inactivation and microRNA-mediated inhibition.
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GUT: The effect of Helicobacterrobacteria eradication on the incidence and mortality of stomach cancer.
Time of Update: 2020-10-28
researchers searched the medical literature as of February 2020 for a randomized controlled study (RCTs) on the risk of subsequent stomach cancer in adults who were positive for healthy Helicobacter pyridobacteria and patients who received endoscopic mucosa removal.
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Cell Death Dis: FBI-1 enhances resistance to triple-negative breast cancer through the miR-30c/PXR path.
Time of Update: 2020-10-28
in the study, researchers found that FBI-1 was able to increase the resistance of triple-negative breast cancer (TNBC) cells to chemotherapy drugs by suppressing the expression levels of micoRNA-30c targeting PXR (pregnancy X-patient).
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Sci Adv: Chen Xuesi's team develops immuno-cocktail therapy with a tumor reduction rate of up to 97.3%
Time of Update: 2020-10-28
immuno-cocktail therapy can induce immunoactive TME (Source: Science Advances) Treatment results in a variety of tumor models show that this cocktail therapy is more effective than traditional chemotherapy combined with immuno-checkpoint inhibitors, which can significantly reduce tumors.
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JAMA: A study of cervical cancer screening rates in 55 low- and middle-income countries in 2005-18.
Time of Update: 2020-10-28
2005-2018, cross-sectional studies of 55 low- and middle-income countries showed significant differences in self-reported lifetime cervical cancer screening rates, with an average screening rate of only 44 per cent.
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JCO: Sytoxides monotherapy treats advanced head and neck squamous cell carcinoma with the lower efficacy than cisplatin.
Time of Update: 2020-10-28
journal of Clinical Oncology recently published the results of a Phase III ARTSCAN trial comparing radiotherapy with cisplatin vs sytoxides monoantigen therapy for local late-stage HNSCC patients.
two groups of distant transfers, the study showed that the partial control of partial late-stage HNSCC was not as good as cisplatin combined radiotherapy.
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Br J Cancer: Causality Exploration of Glioma: A Mondel randomization analysis study for the whole trait group.
Time of Update: 2020-10-28
has a suggestive correlation between white blood cell telomere length (LTL) and all gliomas and GBM, but this correlation is mainly driven by the TRT variant rs2736100.
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Nature: Testing the melanin cell genome is expected to predict melanoma risk.
Time of Update: 2020-10-28
the genomes of melanin cells in human skin, researchers detected 29 pathogenic mutations in 24 different cells.
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Sci Adv: Still staying up late? Scientists have found that circadian rhythm disorders can damage the immune response and accelerate the proliferation of cancer cells!
Time of Update: 2020-10-28
Scientists have previously shown that frequent cross-time zones, as well as shift work, are associated with an increased risk of cancer, but it is unclear how circadian rhythm disorders reduce the body's ability to inhibit the growth of cancer cells on a molecular scale.
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Cell Death Dis: SF3B1 regulates the maturation of KSR2 mRNA and promotes the development of endometrial cancer.
Time of Update: 2020-10-28
PLAD-B inhibits the growth of endometrial cancer researchers identified about 2,000 differential expression genes (DEGs) associated with SF3B1 knock-down in endometrial cancer cells using RNA-Seq.
important, the researchers found that knocking down SF3B1 could save the expression of KSR2 and partially restore the growth of endometrial cancer cells.
