Zhao Wei's team at Shandong University published the results of a new mechanism for the initiation of natural immunity at Nature Immunology.

Recently, Professor Zhao Wei's team from school of basic medicine of Shandong University has made a breakthrough in the research on the mechanism of innate immune activation. The related research results, with the title of "redox homeostasis maintained by GPx4 facilities sting activation", were published online in Nature Immunology, the top international journal in immunology Immunity, 5-year impact factor 23.906).Shandong University is the independent first and corresponding author unit. Jia Mutian, a doctoral student, is the first author and Professor Zhao Wei is the corresponding author.CGAs sting pathway can recognize viral DNA, the unstable leakage of tumor cell chromosome into the cytoplasm of its own DNA, and then initiate innate immunity, and regulate the subsequent adaptive immune response.the imbalance of sting activation is closely related to the occurrence and development of virus infection, tumor and other diseases. It is of great significance to further reveal the mechanism of sting activation and carry out drug research and development on this basis for the prevention and treatment of related diseases.redox homeostasis is a physiological correction response of the body to different stress microenvironments such as virus infection and tumor, and plays an important role in life activities. However, the interaction between redox homeostasis and DNA recognition signaling pathway, especially the role of lipid redox homeostasis in innate immune initiation is not clear.this study found that the lipid redox homeostasis maintained by glutathione peroxidase 4 (GPx4) is essential for sting activation.lipid peroxidation metabolite 4-HNE can promote the carbonylation of sting, and inhibit the palmitoylation and translocation from endoplasmic reticulum to Golgi.GPx4, as a key inhibitor of lipid peroxidation, promotes sting activation by maintaining intracellular lipid redox homeostasis.in this study, DNA virus HSV-1 infection model was used to reveal how the virus regulates lipid peroxidation, inhibits the host's antiviral immune response and realizes immune escape mechanism.this new mechanism of sting activation deepens the understanding of DNA recognition pathway and innate immune activation. At the same time, it provides a new strategy to regulate sting activation by regulating GPx4 activity and lipid peroxidation, which provides a new target for the prevention and treatment of diseases related to sting activation imbalance.Professor Zhao Wei's team has long been engaged in the study of viral infection and innate immunity, revealing the activation and regulation mechanism of innate immunity in the process of viral infection; relevant research results were published in NAT. Immunol. (2020), NAT. Commun. (2016, 2014), J Exp.Med .(2017)、PNAS(2017)、 Cell.Rep (2015) Journal.the above research was supported by national key R & D program, National Natural Science Foundation of China (Youqing, international cooperation program), Newton senior scholar of British Academy of Medical Sciences, and Shandong university climbing program innovation team.article link: the official account is hosted by the microbiology resource center and the big data center of the Institute of Microbiology, Chinese Academy of Sciences. In 2019, Wen Wen TOP101. reversed, which is a simple disease. It is a simple disease to lose weight or reverse the condition. 2. Just now, science released ten scientific breakthroughs in 2019! 3. Science! Broccoli awakens anti-tumor gene! Chinese medical doctor's letter to his father published in Chinese by lancet! Your "honey", my "arsenic..." 6. Drinking, especially those who blush, may face a higher risk of dementia. 7. Nature weighs heavily! The first creature to completely synthesize and completely change the DNA code was born. 8. This is not a big hazelnut! Science has published a new oral insulin, or will replace the traditional injection 9. Science to prevent baldness: start from never losing hair... 10. Can changing sperm speed affect the sex of offspring?