Recently, the team of Professor Yu Jintai from the Department of Neurology of Huashan Hospital Affiliated to Fudan University comprehensively used a new multi-omics integrated research strategy to unearth seven genes such as ACE that can regulate Alzheimer’s disease to varying degrees at the transcription and expression levels ( AD) is expected to be a new drug treatment target for Alzheimer’s
Senile dementia, including Alzheimer's disease, is a severe health challenge facing the world today.
In order to effectively discover the drug targets of AD, the Yujintai team comprehensively used new multi-omics integrated research strategies such as genomics, transcriptomics and proteomics and a variety of machine learning methods to conduct research in the brain and serum specimens.
The dorsolateral area of the prefrontal cortex of the brain is the brain area affected by the AD core, and the expression levels of many AD-related genes in this area are up-regulated or down-regulated
Compared with brain specimens, although the specificity of gene expression in peripheral blood is low, specimens are easy to obtain, so the research and development of genes or protein targets in peripheral blood is more valuable and maneuverable
Yu Jintai said that this suggests that the expression of the ACE gene in peripheral blood still significantly affects the occurrence of AD and can be used as a potential drug target for the treatment of AD
Related paper information: https://doi.
https://doi.
org/10.
1038/s41380-021-01251-6
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