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Yin Yuxin's team discovered a new anti-cancer mechanism of PTEN gene: inhibiting tumor invasion and metastasis by encoding circular RNA circPTEN1

 Last Update: 2022-03-08
 Source: Internet
 Author: User

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On February 8, 2022, Professor Yin Yuxin's team from Peking University School of Basic Medicine published a paper entitled " circPTEN1 , a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling" in Molecular Cancer .
The research paper identified a circular RNA encoded by the tumor suppressor gene PTEN , named circPTEN1 .
circ PTEN1 can interfere with the transcriptional activation of metastasis-critical genes mediated by the TGF-β /Smad pathway, thereby inhibiting the invasion and metastasis of colorectal cancer .
The discovery of circ PTEN1 provides new ideas and potential therapeutic targets for tumor metastasis research .

PTEN (Phosphatase and tensin homolog deleted on chromosome 10) is one of the genes with the highest mutation rate in human tumors.

Tumor database statistics show that there are more than 2700 mutations in PTEN gene in tumors of different tissue origins

The PTEN protein with dual lipid and protein phosphatase activities can inhibit tumors through various mechanisms.

Its classic tumor suppressor pathway is to dephosphorylate cytoplasmic PIP3 to PIP2, inhibit the PI3K/AKT pathway, and thereby regulate cell survival, cell proliferation, and blood vessels.
form

circPTEN1 binds Smad 4 and antagonizes Smad complex formation and nuclear entry

Circular RNA (circRNA) is a type of circular non-coding RNA that is covalently linked and does not have head-to-tail structures at the 3' and 5' ends
.

Studies have revealed that circRNAs are closely related to the occurrence and development of various human tumors, so it is of great significance to further study and clarify the regulatory role and specific mechanisms of circRNAs on the occurrence and development of tumors

Zheng Lin and associate researcher Liang Hui, 2018 graduate students of Peking University School of Basic Medicine, are the co-first authors
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Prof.

Original link: https://molecular-cancer.

biomedcentral.

(Peking University School of Basic Medicine)

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