Ye Zuguang: so far, China has only produced two internationally recognized new Chinese medicines

  Ye Zuguang believes that in the past 30 years, there are not only a large number of new Chinese medicine drugs developed and put on the market in China, but also a new drug array at the forefront of clinical medicine There are many new Chinese medicine drugs with "advantages and characteristics" such as Lianhua Qingwen capsule, compound Danshen dropping pill, Xueshuantong injection, etc., but the new Chinese medicine in China is still short of "take it easy" and causes domestic problems A more "sensational" innovative drug The so-called "get to hand" and "sensationalism" means that this kind of medicine is not dispensable, but "non essential" in the first-line treatment of clinical diseases He gave an example In 2011, China won the Lasker prize, a famous award in biomedical field The prize was not applied for by the R & D personnel of antimalarial drugs such as artemisinin, but was recommended by a third party At that time, it caused a lot of sensation in the pharmaceutical industry of China According to the prize committee, millions of children's lives have been saved as a result of artemisinin China is a big country in natural product research 40% of the international papers on natural product chemistry come from China More than 4000 new natural products are added every year and a large number of active ingredients are found However, "active is not a new drug" Zhang Weidong, a professor at the Second Military Medical University, believes that the main reason for the lack of first-line clinical use of active ingredients is that the target discovery and Optimization Research of new traditional Chinese medicine are not enough and the drug-forming research is not in-depth "Basic research is one of the important sources of innovative drug research and development." According to Ye Zuguang, the production of any new drug is closely related to the progress of basic research and the mastery of new knowledge "Aoji pharmaceutical company, which is mainly composed of returnees, first found a new estrogen er36 receptor in basic research, and then found that the receptor is related to the occurrence and development of several tumors On this basis, a kind of traditional Chinese medicine for the treatment of liver cancer was screened and developed New drug, the drug is expected to complete clinical research in the near future and be approved by the drug regulatory department for listing " "To combine the clinical experience of famous and old Chinese medicine with modern medicine and sublimate it into a perfect innovative new drug is our advantage in new drug research and development, and also an important way to produce new drugs with" hands on " Ye Zuguang used Professor Tang Youzhi, a famous ophthalmologist of traditional Chinese medicine, and pharmaceutical experts to develop a new Chinese medicine eye drops, as an example, to illustrate the importance of the combination of the two Tang Youzhi developed an eye drop for treating eye diseases based on his own clinical experience for many years, but the eye drop has a short time An expert in preparation of Chinese medicine prepared eye drops from eye drops to prolong the time of action of the medicine, thus improving the efficacy of eye drops of old Chinese medicine Facing the embarrassing situation that only two new drugs can be obtained, Zhang Weidong pointed out that "most modern Chinese medicine has no clear molecular target, the mechanism of action is not clear, most of them partially verify the therapeutic effect on some disease animal models, and it is difficult to be accepted by the mainstream academic and industrial circles of international medicine from the level of research and development." Ye Zuguang called that, while strengthening the basic research, we should pay attention to the treatment experience, ideas and their experience in the theory of traditional Chinese medicine, so that it can be combined with modern pharmaceutical and pharmaceutical theory to develop new Chinese medicine with more characteristics and more effective, so as to benefit the whole world and benefit the whole mankind He also suggested that we should strengthen the clinical practice of "scientific research" in TCM clinical hospitals, find, optimize and evaluate the treatment, and finally develop new TCM drugs.