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Yang Weiwei's group discovered a new function of the metabolite pyruvate in DNA damage response

 Last Update: 2022-02-18
 Source: Internet
 Author: User

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Irradiation, as well as most chemotherapeutic drugs, is the main antitumor means, inducing tumor cell death by directly or indirectly causing DNA damage

The latest research by Yang Weiwei's group shows that the glycolytic metabolite pyruvate can mediate the loading of γH2AX into chromatin by promoting the histone chaperone FACT complex, enhance the transmission of DNA damage signals, and promote the repair of damaged DNA, thereby maintaining tumor cells in DNA.

By immunohistochemical analysis of a large number of glioma patient samples, PKM2 S222 phosphorylation was positively correlated with the grade of glioma, and negatively correlated with the prognosis of glioma patients

These findings not only establish a new link between tumor metabolism and DNA damage response, but also provide new strategies for improving the efficacy of glioblastoma treatments

Researcher Yang Weiwei and Associate Researcher Liang Ji of the Center of Excellence for Molecular Cells are the co-corresponding authors of the paper

Article link: http://doi.

Figure: AKT1 phosphorylates PKM2 at serine (S) 222 upon DNA damage

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