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Lung cancer is the most common cause of cancer-related death worldwide, and its treatment remains a formidable challenge
The pyruvate dehydrogenase complex catalyzes the conversion of pyruvate to acetyl-CoA in mitochondria, bridging glycolysis and tricarboxylic acid cycle metabolism
In addition, the phosphorylation level of PDHE1α S327 in tumor tissues of lung cancer patients was correlated with cytoplasmic PDHE1α level, ERK2 activity and NF-κB activation; the cytoplasmic PDHE1α level or PDHE1α S327 phosphorylation level was correlated with the malignancy and prognosis of lung cancer patients
This work discovered a new function of PDHE1α subcellular translocation in tumor immune escape; revealed a new mechanism for phosphorylation to regulate PDHE1α subcellular translocation and PDHE1α subcellular translocation to regulate tumor immune escape; suggesting that inhibition of PDHE1α phosphorylation can Block tumor immune escape and improve the efficacy of tumor immunotherapy
Researcher Yang Weiwei and Zhao Yun from the Center of Excellence for Molecular Cells and Yao Feng, Deputy Chief Physician of the Chest Hospital Affiliated to Shanghai Jiaotong University, are the co-corresponding authors of the paper
Article link: https:// .
MAPK signaling-induced phosphorylation and translocation of PDHE1α promotes tumor immune escape
