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RNAi is a highly conserved post-transcriptional gene silencing mechanism in eukaryotes, and it is also a highly effective antiviral natural immune mechanism
The scientific research team innovatively proposed a drug development concept that targets VSR to release the antiviral potential of RNAi
This study confirmed for the first time that VTP-specific targeting of VSR can effectively release RNAi antiviral immunity in virus-infected cells and in vivo, which fully proves the physiological and functional importance of RNAi as mammalian antiviral immunity
On September 22, related research results were published online on Immunity titled Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo