World Alzheimer's Day, September 21 Read the important achievements of Alzheimer's research in recent years!

!-- 21 September 2020 is the 27th World Alzheimer's Day, commonly known as Alzheimer's disease. There are about 10 million people with Alzheimer's disease, there is a high prevalence, low awareness, low diagnosis and low treatment rate of the "one high three low" condition, in recent years, scientists in the field of Alzheimer's disease research has made what important research results? In this article, the small editor organized the relevant research, shared with you! Photo credit: Wikipedia/public domain1: What exactly does hearing loss cause Alzheimer's disease? Doi:10.1016/j.neuron.2020.08.003 In a study published in the international journal Neuron, scientists from Newcastle University and others have revealed how hearing loss can trigger dementia, and researchers believe that addressing it early may help prevent it.
In an epidemiological study, researchers found that hearing loss is linked to dementia, and that the condition causes one-tenth of the 47 million cases of dementia worldwide; in this study, researchers proposed a new theory to reveal why ear impairments trigger Alzheimer's disease, which researchers hope will help scientists delve deeper into the pathogenesis of Alzheimer's disease and effectively predict the risk of developing alzheimer's disease in the future.
: Study reveals the mechanism by which Alzheimer's occurs: 10.1038/s41586-020-2681-2 Alzheimer's disease is a neurodegenerative disease characterized by the accumulation of beta amyloid plaques in the brain.
to reveal the causes of these lumps, known as plaques, and what role they play in disease progression, is currently a hot topic of research in this area and is critical to the development of prevention and treatment strategies.
recent study found that beta-amyloid has antiviral and antibacterial properties, suggesting a possible link between the immune response to infection and the development of Alzheimer's disease.
clear evidence of this link: a protein called IFITM3 is involved in the immune response to pathogens and plays a key role in the accumulation of beta amyloid proteins in plaques.
researchers say we know that the immune system works in Alzheimer's disease, for example, by helping to remove beta-amyloid plaques from the brain.
but this is the first direct evidence that the immune response promotes the production of beta-amyloid plaques.
"3" Nat Rev Neurol: Artificial intelligence technology may be expected to accelerate and improve the diagnosis of Alzheimer's disease doi:10.1038/s41582-020-0377-8 Recently, a study published in the international journal Nature Reviews Neurology In the study, scientists from institutions such as the University of Sheffield said the use of artificial intelligence (AI) could help quickly diagnose Alzheimer's disease and improve the prognosis of patients; in the paper, researchers analysed how AI could be used in the medical field to help improve the time and economic impact of common neurodegenerative diseases on the NHS, such as Alzheimer's and Parkinson's disease.
The main risk factor for many neurological disorders is age, and as life expectancy increases globally, the number of people with neurodegenerative diseases is expected to reach an unprecedented number, with researchers predicting that the number of Alzheimer's patients alone will triple by 2050. Reaching 115 million, this poses a challenge to health systems; in this study, researchers used AI techniques, such as machine learning algorithms, to detect neurodegenerative diseases before symptoms worsened, improving patients' chances of benefiting from successful disease modification therapies.
depth analysis of the Nature sub-journal! Mysterious link between Alzheimer's disease and diabetes! doi:10.1038/s41594-020-0442-4, published in the international magazine Nature Structural In the study in Molecular Biology, scientists from institutions such as the Urich Research Center in Germany revealed a molecular link between Alzheimer's disease and diabetes; In the
study, researchers used cryogenic electron microscope technology to obtain for the first time clear images of how a single molecule is arranged in protein chains that make up a typical diabetic sediment with a structure very similar to that of the primary fibers in Alzheimer's disease.
About 120 years ago, U.S. doctor Eugene Lindsay Opie discovered unusual protein deposits in the pancreas of people with type 2 diabetes, much like among the brains of people with multiple neurodegenerative diseases, one of the most widespread diseases previously known as adult diabetes. The sediments of the island amyloid protein consist of a small protein harness called profibers, which, in the case of diabetes, consists of the peptide hormone Iapp, which in the pancreas promotes abnormal function and even death of the beta cells responsible for producing insulin, which plays a very important role in helping the body lower blood sugar.
: JAMA Neurol: Deep Analysis! Scientists identify key genetic mutations that can effectively reduce the risk of Alzheimer's disease in people! doi:10.1001/jamaneurol.2020.0414 About 5 million Americans currently suffer from symptomatic Alzheimer's disease, about 1 in 65 and older, and 85 and older One-third of patients; even many have mild cognitive impairment, a precursor to mild Alzheimer's disease, and about half of those with the condition turn into a full-blown Alzheimer's disease, and there are currently drugs that slow the progression of symptoms to some extent, but no available drug can completely block the progression of the disease or prolong the patient's life.
!--/ewebeditor:page--!--ewebeditor:page-title"--Klotho,KL is a trans-membrane protein and longevity factor It plays a key role in reducing age-related disease esoplasms and cognitive decline, with two KL misalmutant mutants (F352V (rs9536314) and C370S (rs9527) 025) When a fully linked imbalance occurs, a functional monotype called KL-VS is formed, and the researchers found that the heterozygosity of KL-VS(i.e., KL-VS) HET-state) can increase the level of KL in the serum, and when compared with individuals carrying hemolysis primary or secondary alleloic genes (KL-VS HET-), it can exert a certain protective effect on the body's healthy aging and longevity.
photo source: Forschungszentrum Jülich/HHU Düsseldorf/Gunnar Schröder(6) Nat Med: The largest proteomics study to date reveals a mysterious link between glucose metabolic proteins and Alzheimer's disease! doi:10.1038/s41591-020-0815-6 We still don't fully understand the pathophysiological mechanisms of Alzheimer's disease, a paper published today In a study in the international journal Nature Medicine entitled "Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation", Scientists from Emory University School of Medicine and others have linked the body's glucose metabolic proteins to the biological properties of Alzheimer's disease (AD) disease in the largest proteomics study to date using quantitative mass spectrometrometrometrology and co-expression network analysis techniques. The
protein network module, which is associated with sugar metabolism as one of the most common modules and one of the most relevant modules related to AD pathology and body cognition, is capable of amassing AD genetic risk factors and small glial cells and astrocyte protein markers associated with anti-inflammatory states, indicating that the biological function it represents plays a key role in the onset of AD, and that proteins from the module increase in cerebrospinal fluid levels in the early stages of disease. In the
study, researchers identified disease-specific proteins and biological processes that could help develop new targeted therapies, and found strong correlations between a group of proteins that regulate the body's glucose metabolism and proteins that play a protective role in small glial and astrological glial cells, or with pathological advances and cognitive impairment of Alzheimer's disease.
: Cell Rep: Inflammation may trigger a deadly cycle of Alzheimer's disease doi:10.1016/j.celrep.2020.02.025, an article published in the international journal Cell In the report, scientists from institutions such as the University of Bonn found that an immune response in the brain appears to play a key role in the progression of Alzheimer's disease, which in some ways may "fuel" and trigger inflammation, which in a sense persists and affects the health of the patient.
The main feature of Alzheimer's disease is the accumulation of beta amyloid protein (A beta), which forms large plaques in the brain, like molecules on the surface of certain bacteria;
In the brain, small glial cells play this role, but doing so triggers a destructive process that appears to be largely directly related to dementia, where special molecular complexes, such as inflammatory small bodies, are activated in small glial cells when exposed to A-beta, and then move like wheels carrying enzymes externally, activating immune messenger molecules and inducing inflammation by directing additional immune cells to the area of action.
: Is herpes virus infection really linked to Alzheimer's disease? Scientists question! Doi:10.1016/j.neuron.2019.11.009 In a study published in the international journal Neuron, researchers from Baylor College of Medicine used the study to refute the link between elevated levels of herpes virus and the risk of Alzheimer's disease, providing a new statistical and computational framework for analyzing large-scale sequencing data.
About 50 million people worldwide are currently suffering from Alzheimer's disease, an aggressive form of Alzheimer's disease that causes memory, cognitive and speech skills, and the number of patients is increasing today;
: Scientists have successfully studied the function of human small glial cells in the brains of mice Promising to develop a new treatment for Alzheimer's disease doi:10.1038/s41593-019-0525-x The human brain has always been a very complex subject of research, brain scans The resolution and the information available are also limited, and researchers are unable to use in-body methods to completely replicate important micro-environments in brain cells. In a recent study published in the international journal Nature Neuroscience, scientists from the Landers Institute for Biotechnology developed a new method that pioneered the transplantation of human brain glial cells into the brains of mice.
!--/ewebeditor:page--!--ewebeditor:page title"--small glial cells are brain cells that are maintained by major complex brain functions, and are found in Alzheimer's disease. Small glial cells play a very important role in the onset of the disease, but it is difficult for researchers to study small glial cells; cultured small glial cells in petri dishes tend to ignore the complex environment needed to maintain cell function, and small glial cells in the brains of model animals such as mice are different from small glial cells in the human brain.
: A gene associated with a rare neurological disorder that regulates the function of key enzymes in Alzheimer's disease doi:10.1016/j.cell.2019.07.043, a study published in the international journal Cell In the study, scientists from Massachusetts General Hospital found that a gene that can mutate causes a rare body balance disorder may regulate the behavior of a particular enzyme that increases an individual's risk of Alzheimer's disease (AD), and the findings may help scientists identify new targets and help develop new therapies that effectively slow or block AD occurrence.
2008, researcher Rudolph E. Tanzi and colleagues identified a number of genes closely related to AD occurrence, including ATXN1, which carries yield.