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World Alzheimer's Day Primary progressive aphasia and its subtyping

 Last Update: 2022-10-02
 Source: Internet
 Author: User

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September 21, 2022 is the 29th World Alzheimer's Day, and the theme is "Know Thyself, Know Others, Prevent Early, Wise Ahead – Hand in Hand for the Future"
.

Let's learn about primary progressive aphasia and its subtyping today
.

Author: Han Ying
Wenyuan: "Subjective Cognitive Decline" public account

Primary progressive aphasia (PPA) is a class of cognitive syndromes
of progressive development.

In the past 10 years, according to the clinical manifestations of language impairment and atrophic brain areas, primary progressive aphasia has been mainly divided into three types: non-fluent primary progressive aphasia (nfvPPA), semantic primary progressive aphasia (semantic variant PPA, svPPA), and logopenic variant PPA (lvPPA).

The clinical manifestations of primary progressive aphasia are characterized by isolated, progressive, and progressive decline in language function, most of which begin between the ages of 55 and 65, with a higher incidence in men than in women
.

The PPA typing and clinical diagnosis proposed by Gorno-Tempini et al.

Before the classification diagnosis, the language function assessment can be performed, the main assessment content is as follows:

VI.
Treatment and prospect of primary progressive aphasia

With the advent of a new generation of improved treatment options for diseases, widely accepted clinical standards, supplemented by biomarkers, will become critical
in the coming years.

In the future, it is hoped that it can be thoroughly treated
through technologies such as gene regulation and monoclonal antibodies.

Reference：Gorno-Tempini, M.
L.
, Hillis, A.
E.
, Weintraub, S.
, Kertesz, A.
, Mendez, M.
, Cappa, S.
F.
, Ogar, J.
M.
, Rohrer, J.
D.
, Black, S.
, Boeve, B.
F.
, Manes, F.
, Dronkers, N.
F.
, Vandenberghe, R.
, Rascovsky, K.
, Patterson, K.
, Miller, B.
L.
, Knopman, D.
S.
, Hodges, J.
R.
, Mesulam, M.
M.
, & Grossman, M.
(2011).
Classification of primary progressive aphasia and its variants.
Neurology, 76(11), 1006–1014.
https://doi.
org/10.
1212/WNL.
0b013e31821103e6

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