With 20 years to defeat the host, bad habits are its accomplices.

decades, health experts have emphasized that many lifestyle habits can lead to heart disease, Alzheimer's disease, type 2 diabetes, and certain cancers that now cause 70 percent of global deaths.
red meat intake, insufficient intake of fruits and vegetables, smoking, alcohol consumption, obesity, lack of exercise ... They significantly increase the incidence of these diseases, and once one of them develops, the risk of developing other diseases increases accordingly.
people always think that these diseases are "old age diseases" that produce inflammation. Originally, inflammation was the immune system's defense against foreign pathogens, but for older people, inflammation itself became an "intruder" - because it was not caused by bacterial infections, so they were not contagious, but were caused by vices and genes. But is that really the case?
Scientists have looked through diseases and found that the hidden "killers" behind them may be bacteria - some of which are so confusing that they tend to hide in cells for long periods of time, "colluding" with the immune system, gradually invading organs, and then slowly crushing the host.
with the continuous progress of human research methods, scientists' understanding of bacteria and diseases is also increasing. They found that inflammation induced by some bacteria exceeds conventional cognition and is consistent with the pathogenesis of many "geriatric diseases".
years, scientists have struggled to find the root cause and cure of geriatric disease, but have repeatedly suffered setbacks. These new findings may mean that spring is coming for people with heart disease and Alzheimer's disease.
" Cold Wave/ Compilation " Geriatrics" variety, the most common of which is gum disease.
, of the University of California, Direct, directly rated gum disease as the "most common human disease." In the United States, 42 percent of people 30 and older have gum disease; In Germany, 88% of people aged 65 and over suffer from gum disease.
it's worth noting that once the gums go wrong, the risk of developing rheumatoid arthritis, Parkinson's syndrome and other geriatrics can also increase dramatically. There are two possible explanations for this phenomenon: first, external factors induce gum disease and other geriatric diseases at the same time; At present, more and more evidence points to the latter.
some of the by-products are very convincing. Some U.S. states use federal Medicaid funds to subsidize residents' efforts to fight gum disease. Statistics show that these states subsidize the cost of treating diseases such as heart disease, diabetes, stroke, and cancer by 31% to 67% less than other states. Many private insurance companies in the United States have made similar discoveries.
, how exactly does gum disease cause other diseases? The immune system's response is key.
have more than 1,000 bacteria in each person's mouth, and mild bacteria often encase malignant bacteria, forming relatively stable groups.
in other parts of the body, such as the skin or the endometrium of the intestine, the bacteria grow on pieces of epithelocyst cells. Toniti points out that the skin of these areas often peels off and the invasive bacteria are removed. But teeth can't peel off the skin, and bacteria survive on hard surfaces and gradually penetrate cells into the body.
when bacteria in the teeth multiply, plaques begin to harden and invade the inside of the gums, creating inflammation. At this point, the body's immune cells swarm, destroying both bacteria and infected human cells. During this process, anaerobic areas are between the gums and teeth, where some anaerobic bacteria multiply wildly. Among them, gum monocytobacteria is particularly dangerous.
Kelorine Genko of Tufts University in Massachusetts, USA, points out that gum monocytobacteria produce specific molecules that block part of the inflammatory process, allowing inflammation to persist. As a result of this situation, the severely reduced inflammatory response has been trying to kill bacteria, but always "unable to help", but eventually killed the human cells - the gum monocytobacteria will take advantage of this opportunity, the wind will engulf the remains of these proteins, which most bacteria do not have a capacity.
same time, human cells that are "killed" by the gum monocytobacteria release iron, which is used by bacteria for their own "expansion".time, the teeth of bacterial infections begin to loosen, while the gum monocytobacteria have long since entered the bloodstream of the body.
, the body's immune system begins to secrete antibodies against these "intruders." However, for the gum monocytobacteria, this antibody to destroy it is not the body's umbrella, but their own pass. Once these antibodies begin to be secreted, patients are significantly more likely to develop rheumatoid arthritis, heart disease, and stroke over the next decade.
explains that this is probably because once the gum monocytobacteria enter the bloodstream, its skin protein changes so that it hides in the white blood cells of the immune system.
same time, gum monocytobacteria invade the endoenometral cells of the arteries and hide them inside the cells, only occasionally invading new cells. As a result, gum monocytobacteria evade antibiotics and the immune system.
However, even if "inhabited" in cells, gum monocytobacteria quietly trigger or block various immune signals and even alter the gene expression of blood cells so that they migrate to other inflammatory areas and make waves again.
, how exactly does gum monocytobacteria link gum disease to diseases such as diabetes and Alzheimer's disease? One possibility is that it increases the overall "inflammatory load", but it is also possible that the gum monocytobacteria directly "force". Because in mouse experiments, the bacteria were detected in the brain, aorta, liver, spleen, kidneys, joints, pancreas and other parts of the body, and many people tested for similar findings.
the role of gum monocytobacteria is particularly prominent in the study of Alzheimer's disease. Currently, two-thirds of dementia is caused by Alzheimer's disease, which is also the fifth leading cause of death in the world. Scientists have long believed that the cause of Alzheimer's disease is the accumulation of amyloid and tau proteins in the brain. However, the accumulation of these two proteins does not necessarily exist in the brains of many people with dementia, and many people who meet these two protein accumulation conditions may not have developed dementia. Most importantly, no treatment for these two proteins can effectively relieve symptoms.
earlier this year, a team of eight U.S. universities teamed up with San Francisco-based company Conaston Healthcare to find that 99 percent of people who died of Alzheimer's disease had gum proteases in their brains that were positively corred with the severity of the disease. This protein digestive enzyme can only be produced by the gum monocytobacteria.
, the researchers also found gum monocytobacteria in the spinal fluid of these patients. About 50 percent of
people without Alzheimer's disease have gum protease and amyloid in their brains, but the content is low.
in mice, the mice in the gum monocytobacteria test group developed symptoms of Alzheimer's disease, and curbing the production of gum proteases was effective in repairing brain damage.
study is enough to make it suspect that the gum monocytobacteria cause Alzheimer's disease, which can take up to 20 years from brain damage to the onset of symptoms. Kathy Lynch of Conaston Medical points out that alzheimer's symptoms may be due to a degree of brain damage caused by gum proteases. researchers still have a question: How do bacteria affect genes, triggering molecular changes that cause disease? Swedish scientists have found that bacteria do have this ability.
most at risk of Alzheimer's disease produce the immunoprotein ApoE, which is destroyed in an outbreak, and gum proteases are particularly good at destroying ApoE.
more than that, gum monocytobacteria can also invade the heart. There is growing evidence of a causal link between it and atherosclerosis. The researchers found in the fat deposits on the inner walls of the arteries that the gum monocytobacteria, which produce blood clots that clog the blood vessels of the heart and brain, eventually lead to a heart attack or stroke.
that in the arterial endoenome, the gum monocytobacteria can trigger molecular changes specific to atherosclerosis. In addition, gum monocytobacteria can also produce lipoproteins that induce atherosclerosis. In animal trials of pigs, arterial damage was similar to that of a high-fat diet. Lakshmia Kesavaru of the University of Florida in the United States has developed active gum monocytobacteria in the aorta of atherosclerotic mice.
American Heart Association acknowledges that gum disease is an independent cause of cardiovascular disease, but does not rate it as a "causal relationship." While treating gum disease can help soften arteries, no studies have shown it can reduce the risk of heart disease or stroke, the association said. Steve Domini, of
Conaston Medical, argues that even if it doesn't effectively reduce the risk of heart disease or stroke, it's because treating gum disease can only relieve the inflammatory load on the arteries, not eliminate the gum monocytobacteria that already exist in the blood vessels.
In order to demonstrate whether there is a causal relationship between gum monocytobacteria and heart disease, more clinical trials are needed, but the real problem is that trials are expensive, difficult, and "bacteria say" is still in the early stages of research. the association between gum monocytobacteria and type 2 diabetes is clearer.
people with diabetes lose insulin sensitivity and are unable to regulate blood sugar on their own. Currently, cases of type 2 diabetes are widespread around the world and lifestyle habits are widely considered to be a potential cause.
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may not stop there. Because high blood sugar damages immune cells, diabetes can exacerbate gum disease. Conversely, gum disease can also exacerbate diabetes. In addition to focusing on changing lifestyle habits, diabetics can also be treated with gum disease, according to the American Society of Periodontology.
recommended by many diabetes research associations, but there is no agency that explicitly lists gum disease as a cause of diabetes. However, there is evidence that the effects of gum monocytobacteria on diabetes are not only reflected in increasing the inflammatory load in the body, but also directly on the liver and pancreas, thereby reducing insulin sensitivity.
, causation is difficult to prove for a complex disease. It is known that mice infected with a large number of gum monocytobacteria will not only develop gum disease, but also develop diabetes, rheumatoid arthritis, atherosclerosis, fatty liver, and Alzheimer's-like symptoms.
in the human body, gum disease can also greatly increase the risk of other diseases. The gum monocytobacteria lurk in the damaged tissue, and the cells are subtly modified to induce specific diseases.
if these geriatric diseases do have a directly related cause, then the treatment will be called out. Moreover, once these assumptions are established, there is a scientific basis for many experiences about living habits. For example, alcoholics are more likely to be infected with gum monocytobacteria, and thus suffer from gum disease; smoking helps gum monocytobacteria invade gum cells; and for Alzheimer's disease, the risk of disease can only be reduced through exercise, perhaps because fitness inhibits inflammation and does not give gum monocytobacteria a good opportunity.
to look at your eating habits. Douglas Kyle, of the University of Manchester in the UK, points out that the human blood contains a lot of latent bacteria, which require trace amounts of iron to stimulate activity and eventually cause disease. This explains why excessive intake of red meat, sugar or fruits and vegetables can lead to geriatrics - all of which increase blood iron. that the academic community should have a clearer understanding of the role of periodontology, which is clearly listed as a cause of geriatric disease. But so far, at least, no official medical institution has advised patients to "see a dentist" to treat geriatrics.
although the link between gum disease and Alzheimer's disease is most evident, the World Health Organization's guidelines for the prevention of Alzheimer's disease, published last May, do not mention the prevention and treatment of gum disease. "
evidence that treating gum disease reduces the risk of dementia," said Benois Varena, WHO's director of health. Margaret
, of the University of Southern California, says flossing can make the brain healthier, but many scoff at the suggestion. It is this mockery, which is based on "common sense", that has so far failed to become a mainstream topic in medicine.
, of Greifswald University in Germany, points out that "dentistry and other medical disciplines have always been distinct and never cooperated." "This leads to a deep-seated belief that diseases such as heart disease are mainly caused by lifestyle problems and are not related to bacteria.
such medical ad conclusions generally take decades to subvert. For example, scientists have shown that stomach ulcers are not caused by life stress or stomach acid, but by Helicobacter helicobacteria. Perhaps in a few decades, many experts will have to admit that amyloid may not be associated with Alzheimer's disease, and that high cholesterol does not induce heart disease.
As the average age of the global population continues to rise, perhaps in a few decades' time, we will face a full-scale outbreak of geriatric disease, when health systems and even social systems in all countries will be under enormous pressure. Humans are in urgent need of some new medical theories for geriatric diseases, and we must face up to the role of bacteria.