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    Home > Active Ingredient News > Study of Nervous System > Winter is heavy and summer is light, seasonal mood disorder! Scientists reveal that hypothalamic neural circuits respond to seasonal light changes

    Winter is heavy and summer is light, seasonal mood disorder! Scientists reveal that hypothalamic neural circuits respond to seasonal light changes

    • Last Update: 2022-09-15
    • Source: Internet
    • Author: User
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    Seasonal changes related to the solar cycle, such as sleep, eating, and mood, are closely related: shorter daytime in winter is associated with seasonal affective disorder, which is characterized by regular depression in winter and mild remission in summer



    1

    Light time causes alternating changes in hypothamus neurotransmitters

    By artificially increasing or shortening the daylight time, the researchers found that 2 consecutive weeks of daylight (19 hours of light per day, 5 hours of darkness) caused an increase in the number of VIP-positive neurons in the SCN region, a decrease in the number of NMS-positive neurons, and a decrease in the number of VIP-positive neurons in short daylight (5 hours of light, 19 hours of darkness), an increase in NMS-positive neurons, showing alternating changes


    2

    Hypothalamic neural circuits respond to changes in the solar cycle

    Studies have shown that dopaminergic neurons in the PVN region (PVN-DA for short) express NMS receptors


    Figure 2: Hypothalamic neural circuits respond to changes in illumination


    summary

    This paper reveals the mechanism by which the SCN ➟PVN neural circuit adapts to changes in the plasticity of neurotransmitters that seasonally illuminated changes, and this adaptive neural mechanism drives the behavioral changes in response.



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