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Researchers at Washington University School of Medicine in St.
This new finding advances the understanding of the causes of itching and may eventually provide solutions
The new study was published in the Oct.
Dr.
By disabling the technique of the visual cortex, the researchers found that even mice without the function of the visual cortex scratched
In a series of detailed experiments, Chen's team found that when other mice scratched, the response required a special set of cells
He explains: "If you delete a specific neuropeptide that carries the ipRGCs signal, the mouse will not scratch the itch
He likened the phenomenon to frogs catching insects for food
"We found that ipRGCs and some cells in the suprachiasmatic nucleus of the brain were very sensitive to scratching movements in mice," he said
Perhaps, he said, because mice are nocturnal animals and often move in dark places, it may be important for them to know if the area where they are active is full of
"You'd better catch it now so that mosquitoes don't bite you too," he said
To further understand the importance of the visual pathways found in these experiments for survival, Chen's team is now studying how mice without visual cortical function respond
This work was supported
Journal Reference:
Fang Gao et al.
