Why is the poisonous "Cruise officinalis" in Yang Guo's body really a medicine?

TextStar Fox

Mr.

The "love flower and highly poisonous" in the novel can be resolved by using "broken bowel" to fight poison with poison.

"The Flower of Love" appears in the seventeenth chapter of the "Lord of the Condor Heroes"

The white mandala flower is also known as the gold flower.

In addition, the grass is real

Here, the author briefly summarizes the pharmacological effects and clinical applications of Qinghua (Dactylorhiza) and Russula (Gelsis)

PART 0 1.

1.

Solanide compounds are a class of ergostane C-26 carboxylic acid lactone steroids, composed of 28 carbon atoms in total, containing 4 rings A, B, C, D and 1 side chain in the molecule E ring, solanolactone compounds are mainly a series of compounds derived from different ring A/B, ring C, ring D and side chain E ring

1.

The content of alkaloids is the largest in the dangling flowers, accounting for 0.

Figure 2 The mechanism of action and pharmacological effects of alkaloids in dangling flowers (love flowers)

1.

Other chemical constituents in datura flower also include flavonoids, sesquiterpenes, lignans, phenolic acids, and polysaccharides

The pharmacological effects of datura

The pharmacological effects of Dactylaceae include: anti-inflammatory, antipruritic effects, effects on epithelial cell mitosis and skin keratinization, cytoprotective effects, effects on the respiratory system, effects on the central nervous system, effects on the cardiovascular system, etc.

The clinical research progress of Dactylaceae

Yang Jinhua is a traditional Chinese anesthetic in ancient China.

In short, even as a kind of toxic Chinese medicinal material, the alkaloids of the toxic components are removed, and the alkaloids of solanaceton and flavonoids can be effectively utilized.
However, the dactylaceae still has broad development prospects
.

PART 0 2.
Guillotine

The highly poisonous plant Gelsemium is also known as the grass, which belongs to the evergreen annual woody vine of Loganiaceae
.
Mainly distributed in China's Zhejiang, Jiangxi and other provinces south of the Yangtze River and Southeast Asia
.
The main active ingredients of Gelsemium are indole alkaloids, including: methyl glucosins, glucosins, cucurbitacin, koumine, sarpagine Class and yohimbane (yohimbane) class
.

Figure 3 Alkaloids in Gelsemium

Pharmacological studies have proved that Gelsemium alkaloids have the effects of analgesia, immune regulation and tumor growth inhibition, and they are clinically used to treat cancer pain, sciatica, smooth muscle colic and other pains, as well as eczema, furuncle carbuncle, and psoriasis.
And other skin diseases have good results
.

In addition, Gelsemium also has a certain therapeutic effect on malignant tumors such as gastric cancer and liver cancer
.
However, due to its highly toxic, and the therapeutic dose is similar to the toxic dose, it is easy to cause poisoning during clinical application, and may even lead to death of the patient
.
In order to avoid its toxic and side effects, the current medicinal use only focuses on external therapies such as pounding or grinding and conditioning, which severely restricts its clinical application
.
The pharmacological effects of Gelsemium include: anti-tumor, analgesia, anti-anxiety, immune regulation, and promotion of hematopoiesis
.

Figure 4 The inhibitory effect of some Gelsemium alkaloids on tumor cells

Gelsemium is used in traditional Chinese medicine for rheumatic arthralgia and neuralgia
.
In recent years, it has also been used externally to treat various pains such as cancer pain, smooth muscle colic, and diseases such as tumors and psoriasis
.
Pharmacological studies have proved that Gelsemium alkaloids have biological activities such as analgesia, anti-anxiety, immune regulation, and inhibition of tumor growth
.
However, because Gelsemium is highly toxic, its clinical application is restricted; after Gelsemium is poisoned, neostigmine, atropine and animal blood (sheep, goose, chicken, etc.
) can be used for treatment, etc.
; current Gelsemium alkaloids are anti-tumor The effect is mainly detected at the cellular level.
Therefore, the effectiveness and mechanism of its anti-tumor effect in vivo need to be further studied
.

Although there is no poisonous plant like love flower in the real world, there is a plant that is similar to it (datum flower)
.
The alkaloids of Dactylaceae can cause human body poisoning through transdermal absorption and blood pathways.
The poisoning method and symptoms are quite similar to the poisoning symptoms of the "love flower" in the novel "The Legend of Condor Heroes"
.

The grass is real, and the Gelsemium alkaloids contained in it have the activity of cholinesterase inhibitors, and can produce M-like effects at toxic doses, which are manifested in the inhibition of the respiratory center and the vasomotor center
.

In the novel, the poison of "love flower" on Yang Guo's body is resolved by the heartbreaker.
In reality, if the poison is poisoned by taking the nectarine flower (love flower), can the poison be used to fight the poison and use the heartbreaker to detoxify it?

The inhibitory effect of the vagus nerve center caused by Gelsemium alkaloid poisoning can be counteracted with atropine (alkaloid contained in the love flower), which indicates that "love flower" and "broken bowel grass" do exist in each other
.
Symptoms such as tachycardia caused by alkaloid poisoning in love flowers can be resisted by the alkaloids contained in the grass.
It has the miraculous effect of fighting poison with poison, but it is quite difficult to grasp the medicinal dosage
.

In the novel, the protagonist Yang Guo judges whether he needs to continue taking it according to his own feelings (by missing the heroine to feel whether he has symptoms of angina)
.
The Legend of Condor Heroes was created by Mr.
Jin Yong in 1959.
At this stage, there are not enough scientific reports to confirm the drug interaction between Dactylaceae and Guillotine.
Mr.
Jin Yong’s mastery of the details in the novel is amazing
.

references:

1.
Li Hao, Wang Yongqing, etc.
; Analysis of the role of love flowers and heart-broken herbs in Jin Yong's martial arts novels; Asia-Pacific Traditional Medicine Asia.
Pacific Traditional Medicine; DOI.
10.
11954/ytctyy.
201605022
.

2.
Chen Chaojie, He Jiali, etc.
; Literature analysis of 1034 cases of Gelsemium poisoning; Journal of Wuzhou University, June 2020, Volume 30, Issue 3
.

3.
Sun Mingxue, Xu Qingqiang, Xiao Kai, etc.
; Research progress in the pharmacology and toxicological mechanism of Gelsemium; The Journal of Toxicology, Volume 34, Issue 4, August 2020
.

4.
Jing Jianan, Lu Shaowa, etc.
; Research progress on the chemical constituents, pharmacological effects and clinical application of Dactylaceae; Chinese Traditional and Herbal Drugs Volume 47, Issue 19, October 2016
.

5.
Shen Baning, Wang Wenzhong, etc.
; Textual Research on the Materia Medica of Gelsemium; Chinese Journal of Ethnomedicine and Ethnopharmacy, Volume 28, Issue 10, May 2019
.