Why is Nature fat and fat? Then ask about the immune response of fat cells in your body.

Introduction to bamboo: when a person's own adipocytes trigger a complex chain reaction of inflammation, which destroys metabolism and weakens the immune response, obesity is quietly worsening at this moment, and people will also be infected with high-risk diseases (including covid-19).recently, a new study reveals how the immune response of adipocytes can worsen obesity, which is published online in nature letters.background obesity affects more than 600 million people worldwide.of all high-income countries, the United States has the highest average adult body mass index (BMI).by 2030, about half of Americans will have a big belly.obesity has long been considered as a major risk factor for type 2 diabetes, nonalcoholic fatty liver disease (NAFLD), cardiovascular disease and various cancers. It is also associated with increased susceptibility and the risk of serious complications of infection.in 2009, the outbreak of H1N1 influenza, obesity is also an independent risk factor for increased mortality; in the current covid-19 pandemic, obesity is also closely related to the infected.many studies have shown that obesity is much more complex than simply eating too much or not exercising enough.previous studies have shown that obesity also reflects the results of various disruptions in which the body converts food into cellular energy.however, it was only recently that scientists began to suspect that these extra calories could alter the behavior of fat cells and thus affect the immune system.adipocytes have been identified as new targets for type 1 interferon, which can be produced by immune cells or adipocytes.these interferons drive a sustained low level of chronic immune response, thereby enhancing "vitality" and promoting the inflammatory cycle in white adipose tissue (WAT).white fat develops into "elephant leg", "unicorn arm" and "beer belly".in turn, this inflammation seems to trigger a series of cellular responses that lead to obesity related diseases, especially type 2 diabetes and NAFLD.this new study shows how type 1 interferon operates along the axis of interaction with interferon alpha receptor (IFNAR), thus triggering a vicious circle of inflammation. Br / >, including changes in the expression of glycolysis and fatty acid production.for example, the team reported that high-fat diet induced increased type I IFN signaling in mice, including increased IFNB1, IFNAR1, oas1a and ISG15 gene expression. importantly, studies have found that human adipocytes retain many of the metabolic changes recorded in mice. this is unexpected, as most scientists have studied interferon type 1, which is related to viral infection and immune cell function. the observation results showed that IFN-I axis could change the inflammatory mechanism of adipocyte core and make them closer to inflammatory immune cells. in addition, interferon type I can change the metabolic circuit of adipocytes, which is the first time to describe the regulation of immune-mediated core metabolism of adipocytes. the specific mechanism of interferon type I used to modify adipocyte core metabolism is still under further study. in addition, the researchers continued to study how adipocytes "mimic" the functional integrity of inflammatory immune cells. these findings directly affect a large number of adult and pediatric patients. in addition to diabetes and NAFLD, the interaction between obesity and the immune system seems to increase the risk of preterm birth and may reduce the body's ability to resist infection. this new study reveals adipocytes' perception of interferon type I, its potential inflammation, and exacerbates obesity related metabolic disorders. in addition, their findings highlight the once underestimated role of adipocytes in the adverse effects of obesity. Ref: Chan, C.C., Damen, m.s.m.a., Moreno Fernandez, M.E. et al. Type I interference sensing unlock domant adipocyte inflammatory potential. NAT common 11, Recommended reading: fight against the epidemic situation, translational medical network content team series reports: [Nature sub journal] snail's "lethal venom" into a "life-saving medicine", so far, the minimum insulin is expected to thoroughly treat diabetes [Focus] cost 900 million yuan, Wuhan nucleic acid detection of about 9.9 million people, confirmed cases of 0! [new discovery] effective treatment of inflammatory diseases drugs have been developed! [Focus] how can ketamine, an anesthetic, rapidly treat depression? The largest study to date reveals the mystery