Why is excessive use of antibiotics prone to Parkinson's disease?

Researchers at the University Hospital of Helsinki in Finland recently published a study showing that the risk of Parkinson's disease increases with the use of commonly used oral antibiotics The study shows that excessive use of certain antibiotics can lead to Parkinson's disease This association can be explained by its destructive effect on the intestinal microbial ecosystem (image source: www Pixabay Com) "The link between antibiotic exposure and Parkinson's disease is in line with the current view that in a large proportion of patients, the pathology of Parkinson's disease may originate in the gut and may be related to microbial changes, which occurred several years before the onset of typical Parkinson's motor symptoms (such as slow, muscle) It is known that the composition of intestinal bacteria in patients with Parkinson's disease is abnormal, but the reason is not clear Our results show that some commonly used antibiotics which have a strong influence on intestinal flora may be a inducing factor " Said Dr Filip scheperjans, a neuroscientist in the Department of Neurology at the University of Helsinki hospital, who led the research team In the intestine, typical pathological changes of Parkinson's disease have been observed for 20 years before diagnosis Constipation, irritable bowel syndrome and inflammatory bowel disease are associated with a higher risk of Parkinson's disease Exposure to antibiotics has been shown to cause changes in the intestinal microbiome, and their use increases the risk of certain diseases, such as mental illness and Crohn's disease However, these diseases or increased susceptibility to infection do not account for the relationship between antibiotics currently observed and Parkinson's disease "This finding may also have an impact on future antibiotic prescribing practices In addition to the problem of antibiotic resistance, antimicrobial prescriptions should also take into account their potential long-term impact on the intestinal microbiome and the development of certain diseases, "scheperjans said.