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New gene for Alzheimer's disease in women discovered
In the United States, more than 5.
Researchers from Boston University School of Medicine (BUSM) and the University of Chicago have discovered a new gene called MGMT that increases the risk of Alzheimer's disease in women
Using several techniques, the researchers performed a genome-wide association study (GWAS) of Alzheimer's disease on two independent datasets
Because of their isolated, isolated society, the Harts have a very small gene pool, making them the subjects of choice for studying the genetic causes of disease
Lindsay Farrer, PhD, director of biomedical genetics at BUSM and the study's senior author, said: "This is one of the few and possibly strongest associations among the female-specific genetic risk factors for Alzheimer's disease
The researchers then further assessed MGMT using multiple types of molecular data and other AD-related features from human brain tissue
Dr.
According to the researchers, this study shows the importance of looking for genetic risk factors for AD that may be specific to only one gender
Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women” by Jaeyoon Chung, Anjali Das, Xinyu Sun, Débora R.
