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The worldwide epidemic of obesity increases the risk of liver fat accumulation, a precursor to liver inflammation and liver disease
The liver is our main metabolic organ and is essential for detoxification and digestion
To achieve this, the researchers used mice as an animal model to obtain data from human individuals, human tissues, and cultures of liver organoids, which are three-dimensional cellular microstructures formed by liver cells in a petri dish
poor prognosis
The scientists then compared the experimental results with patient data in a dataset publicly available from the International Cancer Genome Consortium
"Our findings could help identify individuals with RNF43/ZNRF3 mutations and therefore at risk of developing fatty liver or liver cancer," Merrittsell Hatch said