Why do I get seriously ill after contracting the virus? Immune bias and failure may be the main cause.

After being infected with the new coronavirus, why do some people get seriously ill and some people don't? This has always been an unsolt mystery.
now, scientists write in the latest issue of Science that their latest study suggests that perhaps immune bias and failure are causing the difference between severe and mild cases in patients with neo-coronary pneumonia.
explained that this immune bias may stem from the different responses of our innate immune system to the new coronavirus.
from fruit flies to humans, all organisms have an innate immune system that can quickly detect viruses and other pathogens.
As soon as viruses are detected, the innate immune system attacks them without distinction, mobilizing "sharpshooter" cells that can strike more precisely but at a slower rate, belonging to another branch of the body's pathogen defense system, the adaptive immune system.
researchers analyzed the immune responses of 76 patients with new coronary pneumonia and 69 healthy people.
they found an increase in molecular concentrations that promote inflammatory responses in the blood in patients with severe coronary pneumonia, and identified three molecules that were also associated with inflammation in other lungs.
researchers believe the three molecules and their subjects may be targets for the treatment of neo-coronary pneumonia, and they are testing the therapeutic potential of blocking these molecules in animal models of new coronary pneumonia.
Scientists have also found that the concentration of bacterial fragments in the blood of patients with severe neo-pneumonia, such as bacterial DNA and cell wall materials, increases, and the more fragments there are, the more inflammatory substances circulating in the blood, Physicist.com reported.
, in patients with severe coronary pneumonia, bacterial products that are usually found only in areas such as the intestines, lungs and throat may enter the bloodstream, enhancing the inflammatory response and spreading through the circulatory system to all parts of the body.
study also found that as the disease worsened, key cells in the innococcal immune system in the blood of patients with neo-corona pneumonia did not act because of the presence of viruses or bacteria, but were slow to respond.
, senior author of the study and a senior author of the study, said: "These findings shed light on how the immune system goes wrong during a new coronavirus infection, causing serious illness, and identify potential therapeutic targets.
" ()