When the brain lacks energy, Alzheimer's disease comes to you

This discovery, published in the journal Disease Models and mechanism, prompted people to further study this connection as a basic early driver of Alzheimer's Disease in humans
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In this study, the researchers analyzed the genetic mutations associated with early-onset Alzheimer's disease in the young adult brains of zebrafish
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The research team used cutting-edge genetic technology and mathematical analysis to compare gene activity and found subtle differences between normal fish and mutant fish
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Although the researchers found that different mutations in different genes have many different effects on brain cell function, they also found that mutations in Alzheimer's disease affect a very important cell function-the use of oxygen in the cell to produce energy
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Lead researcher Dr.
Karissa Barthelson from the Alzheimer's Disease Genetics Laboratory at the University of Adelaide said: "This is very interesting because we know that when Alzheimer's disease finally develops, people's brains will be severely lacking in energy
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"When we realized this common connection, our research took another step forward and reanalyzed data from another research group that studied an important Alzheimer’s in mice.
Disease gene
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"We can see a similar effect, which boosts our confidence that we have discovered the basic early drivers of Alzheimer's disease in humans
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The brain is made up of many different types of cells, which have complex ways to generate and share energy
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"It is very satisfying to find that this important common and early factor has promoted the development of Alzheimer's disease
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Researchers say that the cost of Alzheimer's to society is huge.
It is not only taking care of those who cannot take care of themselves, but also losing relationships with loved ones as memory and cognitive abilities decline
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Dr.
Barthelson said: "Energy production is the most basic and important cell activity that supports all other functions, especially in highly active organs such as the brain
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"If we can learn more about the problem of oxygen use and energy production, we may find a way to stop the disease before it starts, which will greatly benefit our aging population
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Karissa Barthelson, Morgan Newman, Michael Lardelli.