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    Home > Active Ingredient News > Drugs Articles > What safety hazards should be paid attention to when operating the high-efficiency wet granulator

    What safety hazards should be paid attention to when operating the high-efficiency wet granulator

    • Last Update: 2022-09-30
    • Source: Internet
    • Author: User
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    High efficiency wet granulator has the advantages of fast mixing, uniform mixture, good absorption of resin to plasticizer, simple machine operation, easy cleaning, strong and durable, compact structure, etc.
    , widely used in plastics, rubber, dyes, food, daily chemical and other industries, is an ideal product
    for scientific research and trial production, formula research and development.

    And according to the needs of the optional frequency conversion speed control device, water ring cooling device
    .

    What are the safety hazards that science should pay attention to when using high-efficiency wet granulators: 1, the compressed air should not be too large: the compressed air does not need to be too large when granulating, after adding raw and auxiliary materials, a little can feel that the auxiliary materials are blown by the wind around the stirring paddle, so as to
    ensure that the shaft will not be powdered during granulation, and the compressed air should be large when cleaning, so as not to flood the water into the shaft.

    2.
    The materials and adhesives added should not be too much, depending on the volume
    .

    Too much will be shut down due to overload of current
    .

    3, cleaning should be thorough, the central shaft part should be cleaned diligently, this part is easy to produce black spots, bringing unnecessary trouble
    to production.

    4, the time of granulation is the shorter the better, the speed of adding the binder (thick paste) is the faster the better, do not take it for granted, the longer the mixing and granulation time, the more uniform the material mixing, before adding the adhesive, the excipient should be mixed evenly in the high-speed stirring, and then add the binder or thick paste, one is to add the binder or thick paste, the other is to try to speed up the speed of adding the binder or the thick paste, the time of adding the binder or the thick paste is too long, On the contrary, it will cause the material mixture to be uneven, and the granulation time is too long, which will also cause the particles or soft materials made to be too hard, affecting the next step, personal experience is that if it is thick paste granulation, the time of adding the thick paste is controlled at 1 to 2 minutes, and after the thick paste is added, it is stirred for 15 to 20 seconds that is, the material is discharged, and the particles become hard
    after the time is too long.

    5, in the process of operation do not use your hands to test the situation of
    soft materials.

    Because the mixing pulp runs at high speed, it is easy to cause production accidents
    .

    6.
    When groping the granulation process, it is necessary to control the mixing time and the amount of adhesive, and the mixing time of dry materials can be selected between 60s-360s, and the specific time should be selected
    by the verification of mixing uniformity.

    If the adhesive is used with starch slurry, it is advisable to 10-15%, the wet mixing time is 60-120s, and the specific bonding dose and time can be stopped
    at 40s, 60s, 80s and other times at the first time to check the properties of soft materials.

    7.
    It is especially suitable for preparations with low main drug content to ensure the content uniformity
    .

    However, pay attention to the order of addition of each ingredient in the prescription, and the main drug should be added in the middle to prevent the main drug from running the ingredients and sinking to the bottom of the pot to affect the content uniformity
    .

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