What is the diagnostic value of Clinica Chimica Acta: 14-3-3 thain and anti-carbide protein antibodies in northern Han rheumatoid arthritis?

Rheumatoid arthritis (RA) cannot be ruled out when rheumatoid factor (RF) or anticyclic gualine peptide antibody (anti-ccp) is negativeHere, we identified the application value of 14-3-3 proteins, anti-carbonamide antibodies (anti-carP), and their potential role in diagnosing RA in conjunction with RF or ANTI-CCPresearchers tested 223 cases of autoimmune diseases in addition to RA in 291 RA patients, and 156 healthy subjects recruited from Han Chinese populations in northern China had serum anti-CCP, RF, 14-3-3-3 and anti-CarP antibodiesWe examined the differences in the levels of these indicators between the groups and compared the correlation between any two of these indicatorsAt the same time, a total of 12 detection strategies are established to maximize diagnostic valueresults show that the levels of RF, antiCCP, anti-CARP and 14-3-3-3 radon in RA patients were significantly higher than in the interfering control group (12.5; 9.36-15.7]、30.7; [25.7-35.6]、1.90; [1.70-2.01]、15.8; 10.8-20.8) and interference control group (124; [1.07-1.41],0.64; [0.42-0.86],0.51; [0.46-0.57],0.33; (0.23-0.44) (P 0.0001) or health control group (103; .99-1.08, 0.49; .38-0.59, 0.28; .21-0.35, 0.55; .27-0.85, respectively, 0.33; .27-0.85, respectively, (P.0.0001)Of all 12 test strategies, any 2 markers, double positive or anti-CCP single positive, can be diagnosed as the highest YI and radon values of the new strategy of RAresults show that anti-CarP antibodies and 14-3-3-3 thin protein can be used as valuable indicators of RA in the Han chinese population in northern China, especially when used in combination with RF and anti-CCP, the value of detection is maximized