What are the most authoritative children's hospitals in the UK, what cutting-edge therapies for the treatment of pediatric neuroblastoma?

Neuroblastoma is one of the most common extracranial solid tumors in children, mainly in infants and young children
.
According to the different high-risk factors, neuroblastoma can be divided into low-risk groups, intermediate-risk groups, and high-risk groups
.
Different levels of risk neuroblastoma are treated differently and have different
prognosis.

According to data from Great Ormond Street Hospital for Children (GOSH), the 5-year survival rate of neuroblastoma in the low- and intermediate-risk groups is 80%-95% after reasonable treatment; The 5-year survival rate for neuroblastoma in high-risk groups is 50% to 60%.

So, how should neuroblastoma be treated?

▲Source: Maker stickers

How are different neuroblastomas treated?

Treatment options for different grades of neuroblastoma vary depending on the condition:

Advanced therapy for neuroblastoma

In recent years, with the continuous improvement of medical technology, innovative therapies for neuroblastoma have gradually increased, which has made great contributions
to prolonging the survival of neuroblastoma patients.

Taking Great Ormond Street Hospital (GOSH) as an example, the current advanced therapies for the treatment of neuroblastoma at Great Ormond Street Hospital include:

In addition, Great Ormond Street Hospital (GOSH) in the United Kingdom also conducts three innovative studies for neuroblastoma, but it should be noted that the research is still in the experimental stage, not open to the public, and has not entered clinical application
.

1

In 2020, a phase I clinical trial conducted by Great Ormond Street Hospital for Children (GOSH) and the Great Ormond Street Institute for Child Health (UCL GOS ICH) at University College London showed that CAR-T cell therapy showed good early results in childhood neuroblastoma, opening the door
to further clinical trials of this approach.

2

In 2021, researchers at Great Ormond Street Hospital for Children (GOSH) in the United Kingdom found that although the clinical manifestations of neuroblastoma vary widely, a major neuroblastoma cell type, sympathoblasts, is present in all patients
.
Sympathetic neuroblasts are expected to be drug targets for the treatment of neuroblastoma, leading to the development of more effective and innovative therapies
.

▲Neuroblastoma cells, source: Great Ormond Street Children's Hospital, UK

3

In 2022, researchers at Great Ormond Street Hospital for Children (GOSH) in the UK are prescribing a new surgical technique
that can improve the effectiveness of neuroblastoma treatment.
These technological innovations are designed to help surgeons illuminate living cancer cells during surgery using a special molecule called a "fluorophores" to accurately see the edges of
cancer tissue in the body.
This "color-coded" procedure can help improve tumor visualization in childhood cancer surgery, remove as much residual tumor as possible, and remove cancer cells that are "invisible" to the naked eye, thereby maximizing the effectiveness and safety of neuroblastoma surgery
.

Great Ormond Street Children's Hospital, UK

Great Ormond Street Hospital for Children (GOSH) is one of the four authoritative children's hospitals in the world and one of the three largest treatment centres for children with cancer/leukaemia in the world.

The Department of Hematology and Oncology at Great Ormond Street Hospital in the UK and University College Hospital London (UCLH) have partnered to become Europe's largest centre for
paediatric and adolescent cancer.
The department is designed to treat the rarest and most complex childhood cancers, with overall survival rates for hematological and oncological diseases comparable to the best results internationally
.

▲Source: Great Ormond Street Children's Hospital, UK

As the UK's leading centre for many different types of malignant and non-malignant pediatric oncology diseases, the Department of Hematology and Oncology at Great Ormond Street Hospital has saved countless lives by providing more effective and personalised treatment options for countless pediatric patients
.

Magnolia Ark has established an in-depth cooperative relationship with Great Ormond Street Hospital for Children, UK, which can provide medical treatment and remote consultation services for children with neuroblastoma and improve the prognosis
of children.
If you want to know more about the treatment of neuroblastoma, or want to make an appointment at Great Ormond Street Hospital for Children, you can call the hotline at 400-081-6600 or add WeChat DrHopeNoah to contact us
.

Reviewed: Great Ormond Street Hospital for Children, UK

Reference source: Great Ormond Street Hospital for Children, UK

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