What are the factors that affect the production of prostaglandin secretion?

Prostaglandin production is affected by many factors, including natural body processes, diet and drugs The body reacts to prostaglandins when tissue or blood vessels are damaged Intake of different types of dietary fat can stimulate the body to secrete prostaglandins, some of which are beneficial, but there are also some potential hazards Finally, the production of prostaglandins can be controlled by non steroidal anti-inflammatory drugs such as aspirin Prostaglandins, the body's fatty acid derivatives, affect almost all human organs Some prostaglandins cause inflammation, fever, and pain in response to disease or injury, while others inhibit inflammation Prostaglandins also cause uterine contractions during pregnancy They act in a similar way to hormones, which also cause changes in body processes, but they are produced in the cells of the body where they need to be Aspirin and other NSAIDs reduce prostaglandin production, pain and inflammation, but they also inhibit the production of beneficial prostaglandins But another drug, called selective COX-2 inhibitors, can reduce pro-inflammatory prostaglandin production while retaining beneficial prostaglandins Prostaglandin production plays an important role in uterine contractions during childbirth To induce labor, prostaglandins may be administered or orally administered to the cervix Interestingly, semen also contains prostaglandins, which is the reason for the pseudoscientific theory that sexual intercourse stimulates childbirth Because prostaglandins are derived and synthesized from fat, diet can be used to inhibit the antagonistic prostaglandins that cause pain and inflammation, or to stimulate the secretion of beneficial prostaglandins to reduce inflammation High saturated fat foods such as red meat and dairy products contain arachidonic acid This fatty acid is an anti prostaglandin precursor that produces inflammation in the body Peanut, seeds and other foods containing vegetable oil and vitamin B contain linoleic acid which can be converted into γ - linoleic acid in vivo Linoleic acid and γ - linoleic acid can stimulate the production of anti-inflammatory prostaglandins Fish oil containing eicosapentaenoic acid, evening primrose oil and borage oil are also rich in γ - linoleic acid There are also other substances that can increase the secretion of beneficial prostaglandins and inhibit inflammatory prostaglandins Bromelain from pineapple has been used in the past to treat inflammatory diseases Although there are different results, it has been confirmed that it can inhibit the secretion of inflammatory prostaglandins Turmeric, mangosteen and pomegranate also inhibit prostaglandin production, but further studies are needed to determine their effects.