West China Hospital 70,000 people study, allergic constitution, not easy to be infected with the new crown

The new coronavirus, which usually infects humans through the respiratory tract, causes damage
to the respiratory system and various organs of the human body.
Since the first outbreak at the end of 2019, the new coronavirus has still ravaged the world, causing a great negative impact
on the world economy and society.

Allergic rhinitis (AR), a non-infectious inflammatory disease of the nasal mucosa, is a type I hypersensitivity disease mainly mediated by immunoglobulin E after the body is sensitized by allergens, and its pathogenesis is very complex, and its impact
on infection with the new crown is not clear.

The team of Zhao Yu and Zhang Wei of West China Hospital of Sichuan University published an article entitled "Impact of Allergic Rhinitis and Asthma on COVID-19 Infection, Hospitalization and Mortality" in the journal "The Journal of Allergy and Clinical Immunology: In Practice" in the field of allergy immunity "
.

The study shows that people with allergic rhinitis, not easy to be infected with the new crown, show a protective effect against the new crown infection, if the patient also has asthma, allergic rhinitis still has a certain protective effect, and asthma alone on the new crown infection protection effect is not obvious
.

In the study, the researchers analyzed 70,557 participants in the UK Biobank database who completed COVID testing between March 16 and December 31, 2020, and divided the participants into 4 groups: allergic rhinitis group (3201), asthma group (8624), rhinitis and asthma group (1407), control group (57325), and the study analyzed the impact of allergic rhinitis or asthma on the risk, severity and mortality of new crown infection
。

Among all participants, 15,690 tested positive for the new crown, of which 4,915 patients were hospitalized with the new crown and 636 patients died from the new crown.

Studies have found that people with allergic rhinitis are not easy to be infected with the new crown and show a protective effect
against new crown infection.
Compared with the control group, people with allergic rhinitis had a 22% lower risk of infection with the new crown
.

In addition, if someone with allergic rhinitis also suffers from asthma, it still shows a protective effect
against new crown infection.
Compared with the control group, people with allergic rhinitis and asthma had a 19% lower risk of infection with the new crown
.

However, the protective effect of asthma alone on new crown infection is not obvious
.

Association of infection, hospitalization and mortality with allergic rhinitis and asthma

For hospitalization rates, the study found that allergic rhinitis did not have a significant effect, on the contrary, asthma was a risk factor
for the severity of the new crown.
For mortality, neither allergic rhinitis nor asthma showed a clear effect
on mortality.

Zhao Yu of West China Hospital of Sichuan University said that although the study is based on previous virus strains, it remains to be studied
whether the Omicron strain currently circulating also has this pattern.
But overall, I think the protective effect is still there
.

At the same time, he also reminded that if the people around him are positive, especially those living in the same household are infected, it is still very important to do a good job of protection, disinfection, and avoid cross-infection in this case, and no one can take it lightly
.

Not only that, but food allergies can cut the risk of contracting coronavirus in half
.

Researchers from the National Institutes of Health, National Institute of Allergy and Infectious Diseases published a paper titled "Risk factors for SARS-CoV-2 infection and transmission in households with asthmatic and allergic" in the Journal of Allergy and Clinical Immunology children.
A prospective surveillance study"
.

The study showed that food allergies can cut the risk of coronavirus infection in half, while asthma is not associated with
an increased risk of coronavirus infection.

Using blood sample testing, the researchers found a link
between the allergy's self-reported symptoms and the level of food allergen-specific IgE in their blood.

The researchers speculate that allergies appear to destroy most of the ACE2 receptors on cells, making it harder for the virus to spread
through the bodies of allergy sufferers.