We found a protein to protect bone and protect bone health

Core tips: (reporter LAN Jianzhong) a research team led by Professor Gao Liuguang of Tokyo Medical and Dental University reported in the online edition of British Journal of nature on the 18th that they found a protein in animal experiments that can increase osteoblasts and reduce osteoclasts, thus protecting bone health, This is the first time in the world to find proteins that act on both osteoblasts and osteoclasts, which may help to develop new methods for the treatment of osteoporosis, rheumatoid arthritis, fractures, etc According to Xinhua news agency, Tokyo, April 19 (reporter, LAN Jianzhong), a research team led by Professor Gao Liuguang of Tokyo Medical and Dental University reported in the online edition of British Journal of nature on April 18 that they found a protein in animal experiments that can increase osteoblasts and reduce osteoclasts, thus protecting bone health, This is the first time in the world to find proteins that act on both osteoblasts and osteoclasts, which may help to develop new methods for the treatment of osteoporosis, rheumatoid arthritis, fractures, etc The team analyzed the proteins secreted by osteoblasts of experimental mice and found that Sema3A, which is related to the growth of nerve cells, can not only promote bone formation, but also hinder the formation of osteoclasts and prevent bone destruction Through gene manipulation, the research team failed to make the Sema3A protein of some experimental mice work normally As a result, compared with the normal experimental mice, the former's Osteoclasts increased by about one time, and the bone density decreased to less than one third of the original level If the protein was injected into the normal experimental mice through the vein, their bone density would increase through the protein treatment, The symptoms of experimental rats with osteoporosis were improved