Wang Xiaofei exposed that Xiao S took Snows to paralyze himself, what is Snow, and how big are the side effects?

On November 21, Wang Xiaofei screened for one day and burned the World Cup
.

He posted on Weibo that "Xu Xidi (Taiwanese artist Xiao S) has been taking Snows for many years, and without a doctor's prescription, he took medicine through a third party with his ID card"
.
Not only that, Wang Xiaofei's mother Zhang Lan also broke the news in the live broadcast room, Xiao S ate 20 capsules a meal, which is a bit over the standard
.

Snownos, scientific name is zolpidem tartrate tablets, is a non-benzene sedative hypnotic drug, with fast action, positive effect, light side effects, commonly used in the treatment of insomnia
.
As Sanofi's blockbuster product, Sinostar has long dominated the global insomnia treatment drug market
.
Sanofi introduced the product to the domestic market in 1997, and its patents have now expired
in all major countries.

Times Finance learned from the instructions of Snows officially released by Sanofi (SNY.
US) that Snows is a non-benzodiazepine sedative hypnotic drug suitable for severe sleep disorders and short-term treatment, which belongs to psychotropic drugs, mainly used for occasional insomnia and temporary insomnia
.
The minimum effective dose of the drug does not exceed 10 mg / tablet, should be taken before going to bed or after bed, only once a night, not multiple times
.

Chronic insomnia is characterized by difficulty falling asleep or staying asleep at least three nights a week for at least a month
.
A study published in the August 2015 issue of Sleep Medicine by researchers at the University of Pennsylvania's Perelman School of Medicine showed that about 9 million Americans rely on prescription sleeping pills to treat chronic insomnia, but may be able to relieve insomnia by taking half the medication, and perhaps even a placebo
.

The findings advocate a smaller dose of sleep medication and placebo medication strategy, a new approach that maximizes the clinical gains for individuals in falling asleep and staying asleep, while reducing side effects and cutting prescription drug costs
.

The clinical effect of sleeping pills cannot last forever, and long-term use increases the risk of psychological dependence and side effects, including daytime sleepiness, nausea and muscle pain
.
Changing the criteria of treatment can maintain response to treatment and reduce the incidence
of side effects.

The study used the sleeping pill zolpidem 10 mg to treat 74 adults with long-term insomnia for 4 weeks
.
People who had a drug response were randomly divided into three dose groups: a 10 mg or 5 mg dose group taken nightly, an "intermittent dose" group of 10 mg 3 to 5 days a week, or a "partially fortified" group that took half a 10 mg capsule and half a placebo capsule each night, and the trial lasted for 12 weeks
.

All three groups were effective at maintaining people's ability to fall asleep and stay asleep, with people in the intermittent dose group sleeping worse and reporting more symptoms
than those in the other dose group.
Studies favor a 'start high, take your time' medication strategy, where patients start with 10 mg per night and then switch to a lower nighttime dose or intermittent administration with placebo on non-medication nights when the desired effect is achieved
.
In 2013, the U.
S.
FDA ordered a reduction in the recommended dose of the sleep drug zolpidem for non-elderly women, citing the risk of health damage the next morning, including reduced driving
alertness.

In the future, this result may affect the prescription of
the drug.
Prescribers can advise patients not only on what medication, at what dose, and/or when, but also on the starting dose and name of the drug, as well as a schedule
for placebo.

Author: K.
K

Resources:

Chronic insomnia sufferers may find relief with half of standard pill dose