Science and Technology Daily, Beijing, October 20th (Reporter Zhang Mengran) The British journal Nature Communications published a newest in cell biology on the 20th.
It is known that misfolding and accumulation of different proteins are hallmarks of neurodegenerative diseases, including prion disease, Alzheimer's disease and Parkinson's disease
Scientist Ina Wahlberg of the German Research Center for Neurodegenerative Diseases and his colleagues hypothesized that the "seed" transmission process, including membrane contact (seen in EV transmission) or direct cell-to-cell contact, can be involved in the cell entry process.
As a proof of concept, the researchers conducted experiments using the glycoprotein of vesicular stomatitis virus and the spike protein of the new coronavirus
Researchers believe that these findings emphasize the possibility of "protein pathogenic seeds" being transmitted via direct membrane contact mechanisms when they have suitable ligands, and may also indicate that viral infection may accelerate the spread of "protein pathogenic seeds"
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