Viagra helps mice have bone marrow stem cell transplants

two clinically approved drugs, Viagra and Prischafo, can quickly and effectively regulate blood stem cells in mouse bone marrow into the bloodstream, researchers said in Stem Cell Reports. This strategy is almost as effective as the current standard scheme for hematopoietic stem cell mobility.
both drugs are approved by the U.S. Food and Drug Administration, they can be tested relatively quickly in human volunteers," the agency said. "Stem cell biologist and co-author E. "If clinical studies are shown to be safe and effective, doctors can consider these findings," Camilla Forsberg said. He
matopoietic stem cell transplantation is a treatment for a variety of blood and immune diseases by replacing abnormal hematopoietic stem cells with healthy cells. The process involves mobilizing hematopoietic stem cells from the bone marrow into the bloodstream and then collecting them for transplantation, between the same person and the recipient. But at present, the main obstacle to hematopoietic stem cell transplantation is the limited supply of supply of supply cells and the lack of effective access.
currently, the standard scheme for hematopoietic stem cells and ancestral cell mobility includes injections of granulocyte collection stimulation factors (G-CSF) for several consecutive days. Although G-CSF is effective in most cases, it is expensive and can have side effects such as nausea, fatigue and bone pain, and is often unsuccessful for cancer patients undergoing chemotherapy.
drug that activates hematopoietic stem cells is Prischafo, but it is not very effective as a single drug. "Better harvesting programs will significantly improve the success rate of current adaptations and open therapy for hematocytocytotherapy." Forsberg said.
recent experiments have shown that increasing vascular permeability helps mobilize hematopoietic stem cells to enter the bloodstream from the bone marrow. Based on this, the Forsberg team tested whether Viagra could be a viable option for hematopoietic stem cell transplants.
found that Viagra itself is ineffective, suggesting that people who currently take viagra for other reasons do not have to worry about inadvertently mobilizing hematopoietic stem cells.
, the number of hematocytes increased nearly threefold compared to control mice in mice using Prischafo alone. But the combination therapy was better - mice taking a dose of Viagra and injecting Prischafu added about 2,500 hematopoietic stem cells to their blood within two hours, 7.5 times as many as the control group. Three days of oral Viagra and one injection of prisafol worked better, with about 2,800 more hematopoietic stem cells, 8.4 times more than in control mice. In addition, the effectiveness of this method can be comparable to 4-day G-CSF treatment.
, however, the researchers say more research is needed to test the safety and effectiveness of this method
(Source: Lu Yi, China Science Journal)
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