Vertigo open "Betaestine" and pay attention to these 3 special groups!

For medical professionals only

Evidence-based medicine, rational use of drugs

 
As one of the most commonly used drugs in neurology, betadustine has the reputation
of "evergreen tree within the gods".
Clinically rational and effective use of this drug is essential to improve the treatment effect of patients, promote patient recovery, and is also one of the keys to the diagnosis and treatment of
vertigo diseases.

With the fair use of betadustine, at least the following needs to be known:







What conditions can be used for vertigo ^[1-7]?
Betadustine is mainly used for:
1, Meniere's disease related to vertigo, tinnitus, hearing loss;
2.
Dizziness, tinnitus and hearing loss caused by cerebral arteriosclerosis;
3.
Orthostatic vertigo and tinnitus caused by hypertension;
4.
Positional vertigo and tinnitus caused by ischemic cerebrovascular disease;
5.
Vertigo
.








Anti-vertigo pharmacological effect ^{[2-7] The anti-vertigo} effect of betastatin is mainly by blocking presynaptic_H3 Receptor and induce_H3 receptor downregulation to increase the turnover and release of histamine, thereby exerting pharmacological effects from the following aspects:
1, can increase blood flow to the cochlear region and the entire brain, eliminate inner ear vertigo, tinnitus and occlusion;
2.
Promote vestibular compensation and accelerate patient recovery after vestibular neuralectomy;
3.
Change the neuronal firing of the vestibular nerve nucleus to improve the severity and frequency of vertigo attacks;
4.
Betastatin is a diamine oxidase inhibitor, which can significantly increase the circulation of blood flow in the heart, brain and surrounding area, and improve blood circulation
.








Be careful to prescribe drugs to these 3 groups ^{of patients [1, 3, 6, 7]} times statin with histamine_H1 The action of a receptor partial agonist, which binds to the_H1 receptor of bronchial smooth muscle, can cause bronchoconstriction; Betastatin binds to_H2 receptors in gastric parietal cells, which may increase gastric acid secretion; Betaxastine, as a synthetic analogue of histamine, may also induce the release of catecholamines in tumors, leading to severe hypertension
.
Therefore, patients with related diseases need to pay special attention:
1.
Bronchial asthma or patients with a previous history of bronchial asthma should use with caution!
2.
Use with caution in patients with active peptic ulcer or previous history of peptic ulcer disease!
3.
Pheochromocytoma patients are banned!

Resources:

[1] Drug information: Betadustine hydrochloride tablets, Lepu Hengjiuyuan Pharmaceutical Co.
, Ltd.
, Sinopharm quasi-word H41022374
.

[2] Drug information: betastatin hydrochloride tablets, Chongqing Kerui Pharmaceutical (Group) Co.
, Ltd.
, Sinopharm Zhun Zi H50020381; 2020/12/01
。

[3] Drug information: Bestatine mesylate tablets, Eisai (China) Pharmaceutical Co.
, Ltd.
, Sinopharm Quasi-word H20040130; 2007/11/14
。

[4] Drug information: Betastatine hydrochloride oral liquid, Heilongjiang Zhonggui Pharmaceutical Co.
, Ltd.
, Sinopharm Zhun Zi H23020091; 2007/09/29
。

[5] Drug information: Betadustine hydrochloride oral liquid, Harbin Renhuang Pharmaceutical Co.
, Ltd.
, Sinopharm Quasi-word H20066114
.

[6] Drug information: Betadustine hydrochloride oral liquid, Daqing Third Pharmaceutical Factory, Sinopharm quasi-word H20056604
.

[7] Drug information: Bestatine hydrochloride sodium chloride injection, Harbin Sanlian Pharmaceutical Co.
, Ltd.
, Sinopharm quasi-word H23023454
.

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