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The importance of controlling the balance of blood sugar to health is self-evident.
In this research, the scientists focused on a protein called apolipoprotein APOA4
Previous studies have shown that lack of APOA4 can lead to glucose intolerance, which is a sign of pre-diabetes
Although the physiological function of apolipoprotein APOA4 is very important, the mechanism of how to use APOA4 to regulate blood sugar levels is not well known, because in the past, almost no molecules that interact with APOA4 were found in various tissues
In this study, the scientists used co-immunoprecipitation combined with mass spectrometry to find a molecule that receives APOA4 signals in the adipose tissue of mice, which is called low-density lipoprotein receptor-related protein 1 (LRP1).
Further experiments showed that LRP1 is like a switch, after combining with APOA4, it controls the absorption of glucose in blood circulation by fat cells
Taken together, this study found that in the function of APOA4 to lower blood sugar, LRP1 is the corresponding receptor, and the two act synergistically to promote the absorption of glucose by mature adipose tissue
Note: The original text has been deleted
Reference materials:
[1] Qu,J.
[2] Receptor protein in adipose tissueplays a role in controlling blood sugar levels.
