U.S. scientists have revealed how chikungi causes joint pain
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Last Update: 2020-12-18
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Source: Internet
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Author: User
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is an acute infectious disease caused by chikungikunya virus, characterized by fever and joint pain. A new study has found the molecular mechanisms of the disease that cause joint pain, helping to develop new treatments.
researchers from Washington University School of Medicine in St. Louis have published their findings in
new issue of the British Journal of Medicine. They found that there is a protein called Mxra8 on the surface of many cells in the joint, and that viruses such as chikungi and Ross River virus, which can cause joint pain, can use this protein as a "grip" to enter the cell.
Researchers infected with chikungi virus mice injected this protein as a "bait", the virus is really "good", most of the virus is combined with artificially injected protein, only a few viruses found a real cell host, these mice have relatively light symptoms of joint pain.
the results show that blocking the virus from touching the protein Mxra8 on cells can help prevent joint pain. But the researchers believe it's best not to develop drugs against the protein between it and the human body, but to develop drugs against the virus to prevent it from reaching the protein on cells.
is mainly endemic in Africa and South-East Asia and is transmitted by mosquitoes. There is a risk of imported cases or local epidemics caused by imported cases in China. (Source: Xinhua News Agency Zhou Zhou)
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