US researchers have developed a new type of wound healing promoting active peptide

Researchers at the innovation research center of tusf University have synthesized a new type of wound healing active peptide, which can promote wound healing by accelerating the formation of blood vessels and epithelial tissues In vitro experiments show that it can increase the rate of angiogenesis by two times The results, published in the Journal of wound repair and regeneration, will help researchers better understand the mechanism of regulating wound healing and provide new treatment strategies for acute and chronic wound healing   "We use collagenase to process extracellular matrix to obtain some specific active peptides, and synthesize a new type of wound healing active peptide by fusing several key peptide fragments together These wound healing peptides can promote the response to trauma, which is to promote angiogenesis and epithelial formation, "said senior author Dr IRA Herman IRA Herman is a professor of molecular physiology and pharmacology at tuff University, a member of the cell, molecular and developmental biology and cell and molecular physiology program of the Saxe Biomedical Sciences Research Institute, and a director of trauma research at the innovation research center of tuff University   "This is the first time to identify and synthesize these active peptides, and we hope that this new technology will be widely used in acute, chronic, burn and scar free wound healing," Herman said   Researchers at tusf University used a three-dimensional trauma model to examine the effects of active peptides on trauma On the third day of the trial, wounds treated with active peptides showed strong signs of wound healing   "We found that collagenase from Clostridium histolyticum can release some bioactive components peptide These peptides can stimulate the proliferation of capillary endothelial cells, promote microvascular reconstruction in two-dimensional model, and induce endothelial germination in three-dimensional wound repair model This means that it has great potential to be used in animal and human wound repair to stimulate the formation of blood vessels and promote wound healing, "said Demidova rice, Ph.D., cell, molecular and developmental biology, Institute of Biomedical Sciences, Saxe University, first author   The formation of new blood vessels from the existing ones is the key step of wound healing, such as knee abrasion, venous ecchymosis ulcer, bedsore and diabetic foot ulcer In the process of tissue repair, sufficient blood supply is needed to bring nutrients, oxygen and signal molecules to the wound site
"Collagenase can be remolded by cleaving collagen, a key component of extracellular matrix We obtained some bioactive fragments by collagenase treatment and synthesized the most effective wound healing active peptide Research shows that it has the potential to be used in individualized regenerative medicine wound healing Using these active peptides to generate thermally stable and portable materials can be used to treat wounded soldiers in war, "Herman said   At present, Herman is leading a number of researchers from different disciplines to carry out wound healing and treatment research The researchers combined the latest progress and technical achievements of wound healing biology, materials science and engineering, and synthesized a series of organ structural materials suitable for individualized regenerative medicine These new materials opened a new way for drug screening, discovery and development Researchers from innovation research center of tusf university are committed to developing the most cutting-edge biological science and technology, and believe that in the near future, personalized treatment products can be produced for clinical wound healing treatment.