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A pair of somites
The spine is the central support structure of all vertebrate skeletons
The spine consists of 33 vertebrae that form pairs of precursor structures called vertebral bodies
"This is the first time that we have been able to create periodic human maturation pairs associated with segmented clocks in the laboratory," said Marina Sanaki-Matsumiya, first author of the study
Create a robust process of somatogenesis
The team cultured human induced pluripotent stem cells (hiPSCs) in the presence of a cocktail of signaling molecules that induced the cells to differentiate
To test whether the segmentation clock regulates somatogenesis in these somatic-like cells, the researchers monitored the expression patterns of the core gene HES7 involved in this process
Ebisuya's team looked at how and why humans differ from other species in embryonic development
The current study also shows a link between the size of somites and the division clock
To investigate this further, Miki Ebisuya and her team are planning to grow somatic-like cells from different species and compare them
"Our next project will focus on creating somatic-like cells from different species and measuring their cell proliferation and cell migration rates to determine how and how somagenesis differs between species," Ebisuya said
article title
Periodic formation of epithelial somites from human pluripotent stem cells.
