"Universal Panda Blood" was successfully developed

March 21st, a study published in Scientific Progress showed that researchers successfully developed "universal panda blood" by anchoring molecules in cell membranes to build a gel network of polysaltic acid-tyrosamine hydrochloride on the surface of red blood cells, enabling the artificial construction and safe blood transfusion of "universal panda blood". The results were jointly carried out by Tang Ruikang, a professor in the Department of Chemistry at Zhejiang University, and Wang Ben, an associate professor at the Second Hospital/Institute of Translational Medicine affiliated with Zhejiang University School of Medicine.
blood types have been found in more than 30 species. Rh blood type system is the most complex type of classified red blood cell blood type system. RhD-positive population accounts for the vast majority of the world's population, RhD-negative is very rare, for example in Asia, more than 99.5% of people are RhD-positive, less than five in 1,000 people are RhD-negative, so called "panda blood."
There are three common blood transfusion methods: one is through the same "panda blood" people to donate, the second is the patient in advance to draw their own blood in case of need, and the third is a one-time input RhD-positive blood emergency.
, the rare source of blood has been plaguing the "panda blood" population. Is there a way to solve the problem of blood transfusion "once and for all"?
, Tang Ruikang, Wang Ben team thought of using "easy-to-look" RhD-positive red blood cells "transformed" into RhD-negative.
do this to scientists? By introducing specially designed anchor molecules into the cell membrane, they copied a root "pillar" anchored to the surface of the red blood cell membrane with phospholipid molecules, and then evenly constructed a network of gels of polysalic acid-tyrosine hydrochloride on the cell surface by copying the material of the salivary acid molecule at the outerst layer of the cell membrane. Scientists "stick" the two to form a stable structure by introducing fixed enzyme molecules and using enzyme catalytic reactions.
this, the original red blood cell membrane out of the tentacles of the head, it is also hidden in the "protective net." With such a layer of "disguise", antibodies can not recognize antigens, will not cause an immune response, will not occur excrete. "Our study turned RhD-positive red blood cells into red blood cells that appear to be red blood cells without RhD antigens, so that clinically, patients can expect emergency blood transfusions without RhD blood type matching." Wang Ben said.
study has been conducted for nearly five years. Wang said the biggest difficulty in the experimental design is to maintain the original physical properties and physiological functions of red blood cells.
The three-dimensional gel network they designed to modify the surface of red blood cells is a completely new strategy, because of its superior bio-affinity and masking of cell membrane surface antigens, rhD-positive red blood cells can be converted into RhD-negative blood transfusion "universal panda blood", for RhD-negative rare blood type clinical transfusion solutions, reflecting the cross-fusion of chemistry and medicine.
Currently, "Universal Panda Blood" has achieved safe single and multiple blood transfusions in mice, with normal in vivo circulation time, and has also verified the complete masking of RhD antigens in rabbits, and does not have immunogenicity. Overall, this study shows good clinical transformation prospects.
Wang Ben revealed that the next step in addition to continuing to promote the "universal red blood cell" research work, clinical plate infusion should also consider the matching type, the problem is more troublesome than the red blood cell matching, the relevant extension of the study is currently planned. "In the near future, there may be more ways to transform cells through chemical biology, give them more new functions, and explore the possibilities for their application in medicine." Wang Ben said. (Source: Cui Xueqin, China Science Daily)
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