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HSD3B1 (red), nucleus (blue) and lipid droplets (black circular area) in human sebaceous glands
A study led by a Southwestern Dermatologist at the University of Texas showed that a common skin inflammation may be caused by poor regulation of sex hormones
Tamia Harris-Tryon, MD, assistant professor of dermatology and immunology
Atopic dermatitis (AD) is a type of eczema
Corresponding author Tamia Harris-Tryon, MD, assistant professor of dermatology and immunology at UTSW, said: "We usually think of eczema as a condition of dry skin.
Dr.
To investigate this problem, Dr.
The researchers injected IL-4 and IL-13 into human sebaceous cells growing in a petri dish, and then used a technique called RNA sequencing to read the gene activity of the entire genome and compare it with those that were not processed with these immune molecules.
Dr.
To determine how this gene affects sebum secretion, the researchers manipulated the activity of HSD3B1 in sebocytes grown in petri dishes
In summary, Dr.
Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis
https://doi.
