Uncovering the mature mechanisms for the production of NK cells promises to lead to the development of new immunotherapy for cancer and infectious diseases

NK cells (natural killer cells) play an important role in the body's fight against cancer and a variety of infectious diseases, and in a recent study published in the international journal The Journal of Immunology, scientists from the University of Lund in Sweden and others developed different stages of the supercell maturation process from bone marrow hematopoietic stem cells and their regulated molecular mechanisms, which are critical to the development of new immunotherapy against cancer.
In the body's immune system, NK cells are front-line cells of the body's defense function, which can identify and kill cancer cells and virus-infected cells;'In order to take full advantage of the properties of NK cells in cell therapy, we first need to understand the mechanisms by which NK cells are produced, and by mapping out the different processes and regulatory mechanisms that allow them to mature from hematopoietic stem cells, they may be able to help researchers better control the development and function of NK cells,' said
researcher Professor Ewa Sitnicka.signaling path, which is critical to NK cell function and maturation
The Notch protein belongs to a family of highly conservative sensors in signaling systems that control cell development in animals and humans. In the paper, the study looked at what happens when the signaling pathline generated by Notch protein activation is turned off, noting that notch signaling pathlines are critical to the development of NK cells and the maintenance of normal function, and when researchers studied notch functions in inactivated blood cells in mice, they found that the number and function of NK cells were affected.
researcher Ewa Sitnicka explains that without the Notch signaling path, NK cells would not mature properly and their numbers would decline, which is important for NK cells to fight cancer and infectious diseases effectively; (Bio Valley)