Revealing the Taboo of Chinese Medicine Compatibility with Modern Technology

In the work of Gao Yue's scientific research team, Jiang Xijuan took a picture of the increasingly widespread use of traditional Chinese medicine in the form of modern preparations, and the occurrence of adverse reactions from time to time made many people worried about this, and even made some foreign people talk about the color change of traditional Chinese Medicine How to make the West understand the connotation of the theoretical system of traditional Chinese medicine, and then accept and use traditional Chinese medicine, is a very difficult work The bottleneck of safety evaluation of traditional Chinese medicine restricts the modernization and internationalization of traditional Chinese medicine At present, with the unremitting efforts of Chinese researchers, this situation is undergoing fundamental changes The research achievements won the first prize of the state, led by Gao Yue, researcher of the Chinese Academy of Military Medical Sciences The research team fully absorbed and applied modern science and technology, such as system biology, bioinformatics, analytical chemistry, etc., and worked hard for more than 10 years, making breakthroughs in the field of key technologies for the safety of traditional Chinese medicine The project team established 8 methods of 3 kinds of technologies, including early toxicity prediction, toxic substance analysis and compatibility taboo evaluation of traditional Chinese medicine, and used this comprehensive technology platform to systematically study the safety of 7 kinds of traditional Chinese medicine that are prone to adverse reactions in clinical practice, clarified the modern biological mechanism of the compatibility theory of traditional Chinese medicine, and demonstrated the "18 anti", cold and heat compatibility, and Glycyrrhiza "coordination drugs" ”And so on The project team is composed of scientific researchers from 7 units, including the Academy of Military Medical Sciences, Zhejiang University, PLA General Hospital, Tianjin University of traditional Chinese medicine, Chinese Academy of traditional Chinese medicine, Shenzhen micro core Biotechnology Co., Ltd and Henan College of traditional Chinese medicine Therefore, it won the first prize of 2013 National Science and technology progress award Why can Glycyrrhiza, the classical theory of traditional Chinese medicine, reconcile all kinds of drugs? Why are ginseng and Veratrum "stars"? Why should decoction have order, time and so on? Taking the participation of human beings in Veratrum as an example, the researchers first studied the material basis of the two "conspiring against each other" The toxic components of Veratrum are mainly a variety of alkaloids represented by Veratrum When people participate in the decocting of Veratrum, the dissolution of these toxic alkaloids increases, but the dissolution of ginsenoside and other useful effective components decreases When different drug ratio, decocting method and time are used, the toxic components will change obviously Therefore, changing the compatibility ratio, decocting method and time has an important impact on the efficacy The researchers further revealed how these alkaloids have toxic effects on human body from the molecular biological level The complexity of traditional Chinese medicine has also been fully verified in this research process It is found that a small amount of ginseng can aggravate the bias of Veratrum, and make its toxicity significantly enhanced Excessive compatibility can mask the bias of Veratrum, and make its toxicity weakened What's more, the toxicity of Veratrum disappeared completely when people participated in the compatibility of Veratrum in a specific proportion From this point of view, anti and non anti, and disharmony, is not absolute, this is the secret of Chinese medicine pay attention to syndrome differentiation? Systematic study for the modern Chinese medicine zhengbenqingyuan Chinese medicine injection why can cause adverse reactions? Taking compound medicine containing cinnabar and realgar, will toxic mercury and arsenic accumulate in the body? As a great initiative, traditional Chinese medicine injection has made great contribution to the innovation and development of traditional Chinese medicine, but it has also become a "Waterloo" for the modernization of traditional Chinese medicine due to serious adverse reactions Taking Houttuynia injection as an example, because of its unique antibacterial effect, it was highly sought after in 2003 when SARS occurred However, due to serious adverse reactions, it was stopped by relevant departments in 2006 Liang Aihua of the Chinese Academy of traditional Chinese medicine led the research team to focus on this topic They found that the allergic characteristics of 10 kinds of injection such as Houttuynia cordata and Shengmai are different from the real allergic reactions, which are "anaphylactic reactions", that is to say, it is not because the human body produces immune antibodies to form allergic reactions, but only because of the stimulation of the drug itself If the dosage of the preparation can be reasonably controlled and the infusion speed can be reduced, the incidence of adverse reactions can be completely reduced Through their research, they found that the sensitizer in Houttuynia cordata injection is a solubilizer used to promote the dissolution and absorption of effective ingredients, and found an ideal alternative There are many toxic components in traditional Chinese medicinal materials, such as realgar and cinnabar For this kind of drugs, the toxicity of Realgar and cinnabar is generally judged by the standards of total arsenic and mercury in the world, and they are listed in the drug ban list The medical profession of our country thinks this kind of practice is unscientific, but it can't get scientific evidence For similar reasons, the United States, Canada and the European Union have blacklisted 70 kinds of traditional Chinese medicines The lack of scientific evaluation methods has become a key issue affecting the trade of traditional Chinese medicine In order to solve the misunderstanding and prejudice, the project team studied the distribution and accumulation characteristics of inorganic arsenic and organic arsenic in organs after realgar administration, found that the distribution and accumulation of realgar arsenic was the highest in the blood, and revealed the possible mechanism of its treatment of leukemia In addition, the inorganic arsenic with high toxicity of realgar can be rapidly transformed into dimethyl arsenic with low toxicity in vivo Researchers further studied the relationship between dosage, time and toxicity, which provided scientific basis for determining the dosage and time of realgar At the same time, researchers also clarified the distribution and accumulation of soluble mercury in human body Which compounds can reduce cholesterol? Which can protect the liver? Will several ingredients be toxic when used at the same time? In order to effectively overcome the key technical problems in the safety research of traditional Chinese medicine, such as various compatibility applications, comprehensive toxicological effects, complex toxicity mechanism, etc., the project team established the key technologies and methods for the early warning, analysis and evaluation of traditional Chinese medicine characteristics under the support of a number of projects funded by the National Natural Science Foundation of China In view of the lack of early toxicity prediction technology, fan Xiaohui's team of Zhejiang University adopted the technology related to toxicology genomics to advance the prediction of drug toxicity to the stage of gene level Generally speaking, gene changes caused by drug toxicity can be found when physiological indexes of the body are not changed, which greatly improves the ability of early warning of toxicity of traditional Chinese medicine This is equivalent to predicting in advance that your body has been over nourished before you get fat, and reminding you to pay attention to what you eat Based on a number of advanced technologies, the project team has built a basic database of potential toxic targets of traditional Chinese medicine, drug hepatotoxicity and all toxic traditional Chinese medicine in Chinese Pharmacopoeia, which integrates the contents of relevant databases in the United States and Japan, and is the most comprehensive and systematic database of toxic traditional Chinese Medicine at present This comprehensive technology platform has directly promoted the research and development process of 103 new drugs Through screening the effective parts and components of several Chinese medicine compounds and single drugs, we found the natural compounds that can effectively reduce cholesterol, and developed a new drug with liver injury protection function, "megrane", which was successfully listed Among them, "Hongyi capsule" has become the first drug for fatigue syndrome caused by altitude hypoxia, which has been used in Wenchuan, Yushu earthquake relief, Antarctic polar exploration, astronaut training and other special environments.