Uncover the secrets of the skin – the formation of skin is different throughout the body

Why are some parts of the body more susceptible to skin diseases than others?

Two new studies by UC Davis Health explore how differences in skin composition can lead to skin diseases such as psoriasis and atopic dermatitis
.

"The skin doesn't have a uniform composition throughout the body," said
Emanual Maverakis, a professor of dermatology and molecular medicine microbiology at the University of California, Davis, and senior author of both studies.

Aging, trauma, environmental and genetic factors can lead to a wide variety of skin problems
.

Body parts determine the structure and function of the skin and the susceptibility to disease

The skin is the largest organ
of the human body.

Differences in the composition of skin lipids and proteins in different parts of the body can also explain why different skin diseases
occur in different parts.

"These findings will lead to non-diagnostic testing of common skin diseases," said
project scientist Alexander Merleev.

Psoriasis and the immune system

In the second study, the team looked at how skin cells interact
with the immune system.

The keratinocytes of the lowest layer of the epidermis secrete immunosuction and immune anti-inflammatory molecules
.

IL-36 is the main mediator
of a subtype of psoriasis, an inflammatory skin disease.

"We found that different layers of the skin secrete different immune mediators, which is an example
of how the skin interacts with the immune system.

Both studies were published in JCI Insight
.

1. Alexander A.

   
   

2. Alexander Merleev, Antonio Ji-Xu, Atrin Toussi, Lam C.