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Figure 5: Stromal enzyme expression in patient samples is associated
with myeloma cell survival.
"We demonstrated that overexpression of stromal enzymes in vitro is associated with decreased proliferation of myeloma cells, and stromal enzymes significantly inhibit myeloma cell migration
.
"
A new research paper published on October 20, 2022, in Volume 13 of Oncotarget, is titled "Serine Protease Matrixase Inhibits Migration and Proliferation of Multiple Myeloma Cells"
.
Multiple myeloma (MM) is an incurable plasma cell malignancy
.
Serine protease matrix enzymes are often dysregulated in human cancers, which promotes tumor progression and metastasis spread
.
The importance of stromal enzymes in hematological malignancies is unclear
.
In this study, researchers Ida Steiro, Esten N.
Vandsemb, Samah Elsaadi, Kristine Misund, Anne-Marit Sponaas, Magne Börset, Pegah Abdollahi and Tobias S.
Slördahl from the Norwegian University of Science and Technology and St.
Olaf University Hospital aimed to investigate the role of matrix enzymes in MM
。
"In this study, we investigated the functional role of stromal enzymes in vitro using human multiple myeloma cells as a model system
.
We also explored the clinical relevance
of matrix enzyme expression using the publicly available MMRF compass dataset.
Our findings may indicate that matrix enzymes play a novel role
in MM pathogenesis.
”
The expression
of mRNA by stromal enzymes and their inhibitors, hepatocyte growth factor activator inhibitors (HAI)-1 and HAI-2, were investigated in patient samples and primary MM cells of human myeloma cell lines (HMCLs).
The researchers further investigated the effects of stromal enzymes on myeloma cell migration and proliferation in vitro.
Using the compass database, they evaluated the clinical relevance
of matrix enzymes in patients with MM.
Stromal enzymes were expressed
in 96% of patient samples and all HMCLs tested.
Overexpression of matrixases reduces cell proliferation and significantly reduces cytokine-induced migration
.
Conversely, matrix enzyme knockdown significantly facilitated migration
.
Mechanically, stromase overexpression inhibits the activation
of Src kinase.
"Our findings may suggest that stromal enzymes as tumor suppressors play a novel role
in the pathogenesis of MM.
"
