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TROPION-Lung02: The first-line treatment of metastatic NSCLC with a new ADC+immunotherapy shows initial results!

 Last Update: 2022-08-20
 Source: Internet
 Author: User

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The 2022 International Association for the Study of Lung Cancer (IASLC) World Conference on Lung Cancer (WCLC) kicked off from August 6 to 9, 2022 in an offline + online format

In this year's WCLC oral presentation session, a study explored the efficacy of a novel antibody-drug conjugate (ADC) targeting TROP2, Datopotamab deruxtecan (Dato-DXd), for the first-line treatment of metastatic non-small cell lung cancer (NSCLC)

background:

Patients with advanced/metastatic NSCLC experience disease progression on first-line immunotherapy, and new treatment options are urgently needed

method:

TROPION-Lung02 (NCT04526691) is a global, dose-escalation, Phase Ib extension study to evaluate the efficacy and safety of Dato-DXd + pembrolizumab ± platinum-based chemotherapy (either dual or triple)

Research design

result:

At data cutoff on May 2, 2022, 88 patients had been treated

Safety Results

Efficacy analysis

in conclusion:

This is the first study to report Dato-DXd + pembrolizumab ± platinum-based chemotherapy in metastatic NSCLC

Editor: Xiaoyuan Typesetting: Xiaoyuan
Execution: Youshi

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