Triptolide may be able to treat prostate cancer
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Last Update: 2012-08-15
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Source: Internet
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Author: User
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Scientists at Cancer Research UK have revealed that male androgens can stimulate the growth of prostate cancer, and that some existing drugs have the potential to treat the disease Androgen receptor (AR) is a large protein, which can control cell division signal and over activate in prostate cancer cells Ar relies on interaction with other proteins such as Hsp90 and p23, which help ar fold into its active form P23 and HSP90 were previously thought to work together to activate AR, but this latest research shows that p23 can also independently improve AR activity independent of Hsp90 Most importantly, this means that blocking p23 may be an effective treatment for prostate cancer that is resistant to Hsp90 inhibitors, which are being tested for breast and prostate cancer The results were published in the journal Molecular Endocrinology In the early days, Hsp90 and p23 were thought to complement each other, but we were surprised to find that p23 can also improve the activity of androgen receptor, even if we use the modified form that cannot bind Hsp90 Drugs that block P23, such as triptolide, can treat some diseases such as arthritis, asthma, etc., which means that the results of this study have moved forward to clinical trials The next step will be to test the drug's effect on prostate cancer cells in the laboratory.
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