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Treat chronic hepatitis B! GSK antisense oligonucleotide drug approved for clinical use

 Last Update: 2021-09-05
 Source: Internet
 Author: User

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Article source: Medical Rubik's Cube Info

Author: Sunshine

August 12, CDE official website shows, GlaxoSmithKline antisense oligonucleotides GSK3228836 injection drugs in clinical trials apply the State Food and Drug Administration approval for the treatment of chronic hepatitis

Source: PharmaGo

Chronic hepatitis B is a chronic disease in which hepatitis B virus (HBV) continues to be infected for more than 6 months, and the liver undergoes varying degrees of inflammatory necrosis (or) fibrosis

Nucleoside and nucleoside analog drugs currently used to treat hepatitis B can inhibit the hepatitis B virus, but cannot completely remove the virus from the body

GSK3228836 is an antisense oligonucleotide that can specifically recognize the mRNA used to express viral antigens (pathogenic proteins) in liver cells infected with HBV, and inactivate viral mRNAs by mobilizing the liver’s own enzymes to inhibit viral proteins HBsAg levels in order to achieve the functional purpose of curing hepatitis B

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