Trans stroke res: exosomes promote recovery after stroke

January 17, 2020 / bioun / -- in an article published in the journal translational stroke research this month, animal scientists funded by the National Institutes of health of the United States showed the brain imaging data of a new stroke treatment method, which can lead to complete recovery of pigs after stroke Stice and colleagues at the UGA Center for regenerative Biosciences report the first observational evidence during midline displacement, which is pushing the brain to one side, suggesting that minimally invasive and non-surgical exosomes can now affect the repair and injury of severe strokes Exosomes are considered to be powerful mediators of long-distance intercellular communication, which can change the behavior of tumor and adjacent cells The results of this study echo the findings of other recent RBC studies using the same permissive exosomes technique (image source: www Pixabay Com) Franklin West, associate professor of UGA, said: "based on the results of exosomes treatment in pigs, it doesn't seem to have the effect of focal volume or midline displacement problems almost as people think This shows that even in some of the most serious cases caused by a stroke, health will be restored as well " Data from the team's study show that untreated brain cells near the site of stroke damage quickly die from hypoxia and could harm millions of healthy cells However, in the brain area treated with exosomes, these exosomes are taken directly from the cold storage and administered intravenously These cells can penetrate the brain and interrupt the process of cell death "The role of exosomes is to communicate with threatened cells and act like anti-inflammatory drugs to disrupt and prevent further damage." In this observational study, the team analyzed brain images taken 24 hours after a stroke Then, they applied recovery scores commonly used in human practice based on pig gait, gait, walking speed and stride By recording the relationship between brain measurement results and functional results, the new assessment scale can better help doctors predict the real-time recovery speed of patients Information source: exosomes promote remark recovery in stroke original source: Samantha E spelling, Erin E Kaiser, Michael M bowler, Brian J jurgieewicz, Robin L Webb, Franklin D West, Steven L Stice Neural Stem Cell Extracellular Vesicles Disrupt Midline Shift Predictive Outcomes in Porcine Ischemic Stroke Model Translational Stroke Research , 2019; DOI: 10.1007/s12975-019-00753-4