Trans fatty acids may increase the risk of Alzheimer's disease by 50%

Recently, an international magazine named "serum elaidic acid concentration and risk of demantia the Hisayama" was published in neurology In the study report, scientists from Kyushu University and other institutions in Japan revealed the relationship between the concentration of trans oleic acid in the body's serum and the individual's risk of dementia through research The researchers found that the intake of junk food rich in trans unsaturated fatty acid would increase the risk of dementia (or Alzheimer's disease) in the population Source: Takanori Honda., et al Doi: 10.1212/wnl.0000000000008464 Trans 18:1 N-9 in serum is an objective biomarker of trans fatty acids in industry Trans fatty acids, or unsaturated fatty acids containing at least one trans conformational double bond, are often found in a variety of foods, including ruminant products and partially hydrolyzed vegetable oil products Now researchers have found that excessive intake of industrial trans fatty acids is often related to a variety of lifestyle related diseases, such as coronary heart disease and diabetes Trans 18:1n-9 (trans fatty acid) is an oleic acid isomer formed by partial hydrogenation of vegetable oil, and trans fatty acid is also the main industrial trans fatty acid In epidemiological studies, researchers have found that specific types of fatty acids, such as n-3 polyunsaturated and saturated fatty acids, are often associated with the risk of dementia and cognitive decline in the population; in contrast, few studies have investigated the association between trans fatty acids and the risk of dementia in the population, and the results of related studies are inconsistent, perhaps because of the researchers The method of evaluating the intake of trans fatty acids in the dietary industry is not accurate The level of anti oleic acid in serum is considered as a major indicator of the intake of industrial trans fatty acids Recent epidemiological studies have shown that the level of anti oleic acid in serum of individuals with coronary heart disease or insulin resistance is higher than that of individuals without disease However, there is no observational study to analyze the level of anti oleic acid in serum and dementia risk of individuals So, in this study, the researchers wanted to analyze the relationship between the level of serum trans oleic acid and the risk of dementia and dementia subtype in the population In this study, 1628 Japanese community residents aged 60 and over who did not suffer from dementia were followed up for about 10 years These participants were screened from 2002-2003 to November 2012 (median 10.3 years, interquartile spacing 7.2-10.4 years) The researchers used gas chromatography / mass spectrometry to measure the level of anti oleic acid in the participants' body and put it into practice Divided into quartiles, the researchers then used a Cox proportional risk model to assess the proportion of people at risk for all-cause dementia, Alzheimer's disease (AD), and vascular dementia through serum trans oleic acid levels Researcher Takanori During the follow-up, a total of 377 participants developed specific types of dementia, including 247 Alzheimer's patients and 102 vascular dementia patients, according to Honda After adjusting for traditional risk factors, the researchers found that the higher level of serum anti oleic acid in the body increased the risk of all-cause dementia (P = 0.003) and Alzheimer's disease (P = 0.02) in the population After adjusting the dietary factors (including total calorie intake, saturated and unsaturated fatty acids intake), these correlations were still significant (P < 0.05); in addition, the researchers also found that the level of serum anti oleic acid in individuals was not significantly related to the risk of vascular dementia The researchers pointed out that the high level of trans fatty acids in the serum of individual body will increase the risk of dementia or Alzheimer's disease by 50% - 75% in the later stage; Alzheimer's disease is one of the main causes of death in the world, and currently there are about 50 million people suffering from various chronic diseases in the world, one quarter of them suffer from Alzheimer's disease; in the article, the researchers also analyzed Other factors that increase the risk of dementia, such as smoking, diabetes and high blood pressure, they found that people with higher levels of trans fatty acids in their serum had a 52% - 74% increased risk of dementia The results of this study may help people avoid unnecessary trans fatty acids in their daily life The World Health Organization also calls for the global elimination of trans fatty acid production and use by 2023 The researchers believe that public health institutions should also formulate policies to reduce industrial production of trans fatty acids in a timely manner, which may effectively prevent or reduce population risk The risk of dementia also reduces the risk of other trans fatty acid related diseases, such as heart disease (bio Com) reference materials: [1] Takanori Honda, Tomoyuki Ohara, Masakazu Shinohara, et al Serum elaidic acid concentration and risk of demantia - the Hisayama study, neurology October 232019, DOI: 10.1212/wnl.0000000000008464 [2] trans fat can increase demantia, Alzheimer's risk by 50 percent, study Says