Traditional Chinese medicine can protect and improve kidney

Business Club January 13 Cordyceps sinensis Cordyceps sinensis can inhibit the formation of subcutaneous immune complex on the glomeruli of Heymann nephritis, maintain the negative charge barrier of glomerular basement membrane, and significantly reduce proteinuria; bailing capsule can significantly improve the activity of NK cells in patients with lupus nephritis, regulate the function of T-lymphocyte subsets, and improve the cellular immune function; Jinshuibao can reduce proteinuria in different stages of diabetic nephropathy, especially in micro The effect of proteinuria was significant Cordyceps can prevent and reduce the damage of aminoglycoside and cyclosporine, stabilize the lysosomal membrane of renal tubular cells, reduce the lipid peroxidation of cells, reduce the calcium content of renal cortex, improve the respiratory function of mitochondria in cells, so as to promote the recovery of glomerular filtration function and renal tubular reabsorption function as soon as possible; in addition, the extract of Artificial Cordyceps can reduce the damage of renal tubular interstitium and prevent Treatment of renal interstitial fibrosis Bailing capsule can also effectively prevent rejection, protect liver and kidney function, stimulate hematopoiesis, improve hypoalbuminemia and hyperlipidemia, reduce infection, etc Moreover, bailing capsule has two-way immune regulation function, can significantly reduce the occurrence of myelosuppression, can effectively protect the function of transplanted kidney, and is an ideal immunosuppressant for organ transplantation Rhubarb has been widely used in the clinical treatment of renal failure for many years, and has achieved positive results It was confirmed that rhubarb has obvious inhibitory effect on mesangial cells (MC), and its mechanism includes: (1) direct inhibition of rhubarb on MC: Anthraquinone and anthrone glucoside of Rhein can directly inhibit the growth of MC, and serum containing rhubarb derivatives can also significantly inhibit the synthesis of MC protein and DNA (2) rhubarb antagonizes the cytokines that stimulate MC proliferation: in vitro, IL-6, TNF and LPS can stimulate MC abnormal proliferation, while the serum containing emodin metabolites can significantly antagonize the stimulation of IL-6, TNF and LPS on MC In addition, emodin can inhibit the production of mcil-6 in human glomeruli in vitro (3) rhubarb inhibited the expression of MC oncogene: the abnormal proliferation of MC was related to the increased expression of MC oncogene Rhubarb could down regulate the over expression of IL-6 and LPS in MCC myc oncogene, and the inhibition of emodin on the expression of MCC mycmrna was related to the inhibition of MC growth Further experiments showed that rhubarb could significantly inhibit the incorporation of mc3h TDR into SV40 transgenic mice, which was positively related to the dose, and also inhibited the expression of sv40mcc mycmrna, and was not affected by actinomycin, which indicated that rhubarb could inhibit the mitotic cycle of MC, which was related to the inhibition of c-myc expression (4) other mechanisms of rhubarb inhibiting MC proliferation: it was found that LDL can stimulate MC abnormal proliferation, while rhubarb can significantly inhibit its abnormal stimulation of glomerular MC In addition, emodin can inhibit the level of membrane related fibronectin (FN) secreted by MC in a concentration dependent manner, and can also antagonize the stimulation of transforming growth factor β (TGF β) on mcfn In recent years, many scholars of Tripterygium wilfordii have observed the pharmacological effects of Tripterygium wilfordii on MC, including: (1) direct inhibition of glomerular MC: it has been found that Tripterygium wilfordii glycoside can inhibit the growth of MC at the concentration of 1-5g / ml in vitro, and the same results have been obtained in the serum of mice fed with Tripterygium wilfordii glycoside, but the cytotoxic effect can occur if the concentration is too high (2) effect on the production of reactive oxygen species in MC: it was found that the production of living oxygen species was significantly increased in the abnormal hyperplasia of glomerular MC, and Tripterygium wilfordii may inhibit the production of reactive oxygen species in glomerular MC (3) antagonizing the autocrine of some cytokines in glomerular MC: Tripterygium wilfordii monomer T4 can significantly inhibit the proliferation of mesangial cells and the production of IL-1, and its inhibition effect is dose-dependent and time-dependent Ligusticum chuanxiong is a kind of medicine which can promote blood circulation and remove blood stasis It has a good therapeutic effect on blood stasis syndrome caused by various reasons It is also commonly used in the treatment of hypercoagulable state of glomerular diseases When tetramethylpyrazine was added into the culture system of human fetal glomerular MC, the number of glomerular MC was significantly lower than that of the control group, and the content of IL-6 in the glomerular MC of the tetramethylpyrazine group was also significantly lower than that of the control group, suggesting that the mechanism of tetramethylpyrazine inhibiting the proliferation of glomerular mesangial cells was caused by reducing the spontaneous secretion of IL-6 in the glomerular MC Astragalus membranaceus In kidney diseases, Astragalus membranaceus is often used in the treatment of diabetic nephropathy (DN) and nephrotic syndrome (NS) Astragalus injection can reduce the production of TGF β 1 and Ⅳ - C in early diabetic nephropathy, reduce non enzymatic glycosylation, thus protect renal function and delay the development of DN The protective effect on type 2 diabetic kidney may be related to the down-regulation of TGF - β 1 expression in renal tissue Astragalus membranaceus can induce TGF - β 1 The production of endogenous Smad7 was decreased, which played an anti fibrosis role Astragalus injection can also reduce platelet adhesion rate, increase renal blood flow and promote protein synthesis It was found that TNF - α was involved in the pathogenesis of NS Astragalus membranaceus could reduce the immune damage of NS and the side effects of cyclophosphamide by regulating TNF - α production Astragalus can also improve the oxidative stress state of primary nephrotic syndrome In addition, Astragalus can inhibit the production of IL-6 in mesangial cells, and its inhibitory effect will increase with the increase of dose, which may be one of the mechanisms of Astragalus in the prevention and treatment of glomerulosclerosis.