Top journals of Chinese scholars have published articles exploring early intervention in blind eye disease in old age

the progress of retinal and eye research
Progress in Retinal and Eye Research,
this is the second time xu peace has been invited to publish a review article in the journal. Its first issue, Sub-Inflammation in the Aging Retina, published in 2009, has been cited more than 430 times. This paper first put forward the concept of para-inflammation in the field of ophthalmology, and expounded its role in the onset of macular degeneration in old age, which aroused widespread concern in the ophthalmology community.
the retina is a soft, transparent film in the human eye, and when we look at something, the image of the object falls on the retina through a receding system. Like a photosynthel negative in a camera, it specializes in photosynthelography. Once retinal lesions occur, failure to receive timely and effective treatment will result in lifelong blindness.
age macular degeneration, glaucosis, diabetic retinal lesions are common in the elderly typical blinding eye disease, once the rate of blindness is much higher than the general eye disease, known as "vision killer." As we age and the body ages, the risk of these de-desitive eye diseases increases. Epidemiological results show that the incidence of macular degeneration in China over 60 years of age has reached 6%-11%, and continues to rise with age, the total number of patients as high as 10 million.
blind eye disease is very harmful, but the incidence rate is higher year by year, one of the main reasons is that early detection and early intervention early treatment can not be achieved. Taking glare as an example, the data show that the prevalence of glare in people over 40 years of age in China is 2.3%, and the blindness rate is about 30%. By 2020, there are expected to be 21 million glare sufferers in China, resulting in nearly 6.3 million blind people and more than 10 million visually impaired people. However, in the investigation of glare patients in China, it was found that the social awareness of the disease was only 63%, and two-thirds of patients had reached the middle and late stages of diagnosis. This is closely related to the human failure to fully understand the pathogenesis of such diseases.
In this study, Xu's team took eye immunity as the main entry point and explored the effects of aging on retinal immunomodulation, as well as the relationship between steady-state control of retinal immunopopulation and sub-inflammation under aging conditions. Xu peace pointed out that the next step of research will be combined with Eyre's clinical resources, seeking to find early abnormalities, further understand how aging affects eye immune regulation and then lead to disease, looking for elderly macular degeneration, diabetic retinal lesions and other early intervention of eye diseases, so that these blind eye disease patients in irreversible visual impairment before the occurrence of timely treatment.
in Xu's view, the ability to carry out multi-center research is one of the key factors for the achievement of medical clinical research projects in the concept of evidence-based medicine promoted by the medical community today. With more than 400 hospitals around the world, Eyre Ophthalmology has a great advantage in conducting large-scale, multi-center research.
experts believe that Xu Peace's research is further than nine years ago, from obtained immunity to inherent immunity, from immune immunity and local immune regulation to systemic immune regulation, a comprehensive summary of recent years on the role of immune regulation in retinal aging and de-regulation diseases research progress. (Source: Science Network Xiao Jie)